Naissides M, Pal S, Mamo J C L, James A P, Dhaliwal S
School of Public Health, ATN Centre for Metabolic Fitness, Curtin University of Technology, Perth, Western Australia, Australia.
Eur J Clin Nutr. 2006 Jun;60(6):740-5. doi: 10.1038/sj.ejcn.1602377. Epub 2006 Feb 1.
To elucidate whether the chronic consumption of dealcoholised red wine (DRW) (polyphenol-rich component) and/or red wine (RW) improves vascular function in hypercholesterolaemic postmenopausal women.
DESIGN, SUBJECTS AND INTERVENTION: A randomised parallel-arm study. Forty-five hypercholesterolaemic postmenopausal women were randomised into either water, DRW or RW group for 6 weeks following a 4 week washout. Fasting measures of central haemodynamic parameters, arterial wave reflection and endothelial nitric oxide were taken at 0 and 6 weeks.
Clinic in the School of Public Health, Curtin University.
There were no significant between group differences in arterial stiffness as measured by augmentation index (AIx) and augmentation pressure (AP). However, a significant within group decrease in AIx (-9%, P=0.02) and AP (-12%, P=0.02) was observed following DRW consumption. No significant changes were observed in central haemodynamic parameters and endothelial nitric oxide levels following DRW and RW consumption, compared to water.
Neither the chronic consumption of DRW nor RW improved markers of arterial stiffness, compared to control. However, the significant within group improvements in these indices following the consumption of DRW cannot be overlooked and warrant further investigation.
阐明长期饮用脱醇红酒（DRW）（富含多酚成分）和/或红酒（RW）是否能改善高胆固醇血症绝经后女性的血管功能。
设计、研究对象与干预措施：一项随机平行组研究。45名高胆固醇血症绝经后女性在经过4周洗脱期后，被随机分为水、DRW或RW组，为期6周。在第0周和第6周时，对中心血流动力学参数、动脉波反射和内皮一氧化氮进行空腹测量。
科廷大学公共卫生学院诊所。
通过增强指数（AIx）和增强压（AP）测量的动脉僵硬度在组间无显著差异。然而，饮用DRW后，组内AIx（-9%，P = 0.02）和AP（-12%，P = 0.02）显著降低。与饮用清水相比，饮用DRW和RW后，中心血流动力学参数和内皮一氧化氮水平无显著变化。
与对照组相比，长期饮用DRW和RW均未改善动脉僵硬度指标。然而，饮用DRW后这些指标在组内的显著改善不容忽视，值得进一步研究。
