Naissides Mary, Mamo John C L, James Anthony P, Pal Sebely
Department of Nutrition, Dietetics and Food Science, School of Public Health, Curtin University of Technology, Kent Street, Bentley, Western Australia 6102.
Atherosclerosis. 2004 Dec;177(2):401-8. doi: 10.1016/j.atherosclerosis.2004.07.025.
Postprandial lipoproteins are potentially atherogenic. The aim of this study was to elucidate whether acute consumption of red wine (RW) and dealcoholised red wine (DRW) regulates postprandial lipid and lipoprotein metabolism in 17 dyslipidaemic postmenopausal women. A mixed meal accompanied by either water, RW or DRW was consumed on three separate visits, in random order, 2 weeks apart. One fasting and 6 hourly postprandial blood samples were taken for lipid analysis. Results showed no significant quantitative changes in postprandial apolipoprotein (apo) B48 levels following the consumption of DRW or RW compared to water. However, qualitatively, DRW may reduce arterial exposure to apoB48-containing lipoproteins over the 6-h postprandial period measured. DRW consumption did not significantly change postprandial TG or insulin levels. A 35% (p = 0.02) increase in postprandial triglyceride (TG) levels and a 54% (p = 0.02) increase in insulin levels were observed following RW consumption, compared to water. In conclusion, acute DRW consumption had no effect on postprandial lipid and lipoprotein metabolism in dyslipidaemic postmenopausal women. However, the consumption of full-compliment RW exacerbated the postprandial lipaemic and insulin response over the 6-h period. Collectively, our findings suggest that neither polyphenols nor red wine reduce atherosclerotic risk by acutely modulating postprandial lipaemia over a 6-h period.
餐后脂蛋白具有潜在的致动脉粥样硬化作用。本研究的目的是阐明急性饮用红酒（RW）和脱醇红酒（DRW）是否能调节17名血脂异常的绝经后女性的餐后脂质和脂蛋白代谢。在三次单独的就诊中，以随机顺序、间隔2周分别饮用一份搭配水、RW或DRW的混合餐。采集一份空腹血样和餐后每6小时的血样进行脂质分析。结果显示，与饮用清水相比，饮用DRW或RW后餐后载脂蛋白（apo）B48水平无显著定量变化。然而，从定性角度来看，在测量的餐后6小时内，DRW可能会减少动脉与含apoB48脂蛋白的接触。饮用DRW并未显著改变餐后甘油三酯（TG）或胰岛素水平。与饮用清水相比，饮用RW后观察到餐后甘油三酯（TG）水平升高35%（p = 0.02），胰岛素水平升高54%（p = 0.02）。总之，急性饮用DRW对血脂异常的绝经后女性的餐后脂质和脂蛋白代谢没有影响。然而，饮用全成分RW会在6小时内加剧餐后血脂和胰岛素反应。总体而言，我们的研究结果表明，多酚类物质和红酒均不能通过在6小时内急性调节餐后血脂来降低动脉粥样硬化风险。
