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果蝇 Krüppel 突变体胚胎同源异形和体节基因表达的相关变化。

Correlative changes in homoeotic and segmentation gene expression in Krüppel mutant embryos of Drosophila.

机构信息

Developmental Genetics Laboratory, Imperial Cancer Research Fund, Mill Hill Laboratories, London, UK.

出版信息

EMBO J. 1986 Jul;5(7):1659-65. doi: 10.1002/j.1460-2075.1986.tb04409.x.

DOI:10.1002/j.1460-2075.1986.tb04409.x
PMID:16453692
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1166992/
Abstract

Mutations of the segmentation gene Krüppel (Kr) cause deletions of contiguous sets of body segments from the middle region of the Drosophila embryo. We have monitored expression in situ of three other genes implicated in the establishment of the body plan, namely hairy (h), fushi tarazu (ftz) and engrailed (en), in mutant Kr embryos. Our results show that the pattern of expression of all three genes depends upon Kr activity and are consistent with a hierarchical model of segmentation gene activity. In addition, we find that the initial expression of the homoeotic selector gene Ultrabithorax(Ubx) follows a novel pattern in Kr embroys indicating a close integration of the spatial control of homoeotic and segmantation gene expression.

摘要

基因突变会导致果蝇胚胎中段连续的身体部位缺失。我们监测了另外三个与身体形态建立有关的基因 hairy（h）、fushi tarazu（ftz）和 engrailed（en）在突变 Kr 胚胎中的原位表达。我们的结果表明，这三个基因的表达模式都依赖于 Kr 的活性，并且与一个分层次的基因活性模型一致。此外，我们发现同源异形选择基因 Ultrabithorax(Ubx)的最初表达在 Kr 胚胎中呈现出一种新的模式，这表明同源异形和分段基因表达的空间控制紧密结合。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2104/1166992/bd959fdafa8c/emboj00170-0246-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2104/1166992/c1cf0bcfacef/emboj00170-0243-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2104/1166992/cf171a22bbc2/emboj00170-0244-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2104/1166992/3b86f0a5b7b8/emboj00170-0245-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2104/1166992/a137d3ffed15/emboj00170-0246-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2104/1166992/bd959fdafa8c/emboj00170-0246-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2104/1166992/c1cf0bcfacef/emboj00170-0243-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2104/1166992/cf171a22bbc2/emboj00170-0244-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2104/1166992/3b86f0a5b7b8/emboj00170-0245-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2104/1166992/a137d3ffed15/emboj00170-0246-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2104/1166992/bd959fdafa8c/emboj00170-0246-b.jpg

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引用本文的文献

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Molecular characterization of spalt, a homeotic gene required for head and tail development in the Drosophila embryo.果蝇胚胎头部和尾部发育所需的同源异形基因 spalt 的分子特征。
EMBO J. 1988 Jan;7(1):197-204. doi: 10.1002/j.1460-2075.1988.tb02800.x.
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Head and tail development of the Drosophila embryo involves spalt, a novel homeotic gene.

本文引用的文献

1
The distribution of Ultrabithorax transcripts in Drosophila embryos.果蝇胚胎中 Ultrabithorax 转录本的分布。
EMBO J. 1985 Jul;4(7):1689-700. doi: 10.1002/j.1460-2075.1985.tb03838.x.
2
Genes controlling segmental specification in the Drosophila thorax.控制果蝇胸部体节特化的基因。
Proc Natl Acad Sci U S A. 1982 Dec;79(23):7380-4. doi: 10.1073/pnas.79.23.7380.
3
Mutations affecting segment number and polarity in Drosophila.影响果蝇体节数量和极性的突变
果蝇胚胎头尾的发育涉及 spalt，一个新的同源异型基因。
EMBO J. 1988 Jan;7(1):189-96. doi: 10.1002/j.1460-2075.1988.tb02799.x.
4
Conserved sequence elements in the 5' region of the Ultrabithorax transcription unit.Ubx 转录单元 5' 区的保守序列元件。
EMBO J. 1987 May;6(5):1393-401. doi: 10.1002/j.1460-2075.1987.tb02380.x.
5
A genetic screen for zygotic embryonic lethal mutations affecting cuticular morphology in the wasp Nasonia vitripennis.对影响丽蝇蛹集金小蜂表皮形态的合子胚胎致死突变进行的遗传筛选。
Genetics. 2000 Mar;154(3):1213-29. doi: 10.1093/genetics/154.3.1213.
6
Molecular heterochrony in the early development of Drosophila.果蝇早期发育中的分子异时性
Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):212-6. doi: 10.1073/pnas.97.1.212.
7
The Drosophila Polycomb-group gene Enhancer of zeste contains a region with sequence similarity to trithorax.果蝇的多梳蛋白家族基因“小体节”增强子包含一个与三胸节蛋白具有序列相似性的区域。
Mol Cell Biol. 1993 Oct;13(10):6357-66. doi: 10.1128/mcb.13.10.6357-6366.1993.
8
Selective repression of transcriptional activators at a distance by the Drosophila Krüppel protein.果蝇Krüppel蛋白对远距离转录激活因子的选择性抑制
Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11361-5. doi: 10.1073/pnas.90.23.11361.
9
Mapping and mutagenesis of the amino-terminal transcriptional repression domain of the Drosophila Krüppel protein.果蝇克虏伯蛋白氨基末端转录抑制结构域的定位与诱变
Mol Cell Biol. 1994 Jun;14(6):4057-66. doi: 10.1128/mcb.14.6.4057-4066.1994.
10
A novel zinc finger gene on human chromosome 1qter that is alternatively spliced in human tissues and cell lines.一个位于人类1号染色体末端的新型锌指基因，该基因在人类组织和细胞系中存在可变剪接。
Am J Hum Genet. 1993 Jan;52(1):192-203.
Nature. 1980 Oct 30;287(5785):795-801. doi: 10.1038/287795a0.
4
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Krüppel, a gene whose activity is required early in the zygotic genome for normal embryonic segmentation.克鲁佩尔基因，其活性在合子基因组早期对正常胚胎分割是必需的。
Dev Biol. 1984 Jul;104(1):172-86. doi: 10.1016/0012-1606(84)90046-0.
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Homoeosis in Drosophila: the ultrabithorax larval syndrome.果蝇中的同源异形现象：超双胸幼虫综合征。
Proc Natl Acad Sci U S A. 1984 Jan;81(2):545-9. doi: 10.1073/pnas.81.2.545.
7
Studies of nuclear and cytoplasmic behaviour during the five mitotic cycles that precede gastrulation in Drosophila embryogenesis.对果蝇胚胎发育中原肠胚形成前五个有丝分裂周期期间细胞核和细胞质行为的研究。
J Cell Sci. 1983 May;61:31-70. doi: 10.1242/jcs.61.1.31.
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Developmental compartmentalisation of the wing disk of Drosophila.果蝇翅盘的发育分区
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