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人类妊娠初期蜕膜、滋养层与淋巴细胞之间的超微结构关系。

Ultrastructural relationships between decidua, trophoblast and lymphocytes at the beginning of human pregnancy.

作者信息

Tekelioğlu-Uysal M, Edwards R G, Kişnişçi H A

出版信息

J Reprod Fertil. 1975 Mar;42(3):431-8. doi: 10.1530/jrf.0.0420431.

DOI:10.1530/jrf.0.0420431
PMID:164546
Abstract

Between the 20th and 40th day of pregnancy, human decidual cells in the endometrial connective tissue come into direct contact with the trophoblastic cells eroding the stromal tissue. Fibrillar deposits of maternal origin were randomly distributed between the maternal and fetal sites and did not form a continuous barrier. Structural features were prominent in the maternal and embryonic cells. Large decidual cells were intermingled with trophoblastic cells, and there was little intercellular material. Small developing decidual cells arose around the maternal precapillary arterioles and capillaries and were closely accompanied by lymphocytes. Fully developed decidual cells exhibited a fine structure characteristic of a state of active secretion, and trophoblastic cells gave structural indications of producing protein. The aggregates of decidual and trophoblastic cells in the human endometrium during early pregnancy ('deciduotrophoblastic complex') may function as a local humoral regulator releasing chemical factors and partaking in the establishment of immunological privilege at implantation.

摘要

在怀孕第20天到第40天之间,子宫内膜结缔组织中的人蜕膜细胞与侵蚀基质组织的滋养层细胞直接接触。母体来源的纤维状沉积物随机分布在母体和胎儿部位之间,并未形成连续的屏障。母体和胚胎细胞的结构特征很突出。大的蜕膜细胞与滋养层细胞混合在一起,细胞间物质很少。小的正在发育的蜕膜细胞出现在母体毛细血管前小动脉和毛细血管周围,并紧密伴有淋巴细胞。完全发育的蜕膜细胞呈现出活跃分泌状态的精细结构特征,滋养层细胞给出了产生蛋白质的结构迹象。妊娠早期人子宫内膜中蜕膜细胞和滋养层细胞的聚集体(“蜕膜滋养层复合体”)可能作为局部体液调节因子发挥作用,释放化学因子并参与着床时免疫特惠状态的建立。

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Ultrastructural relationships between decidua, trophoblast and lymphocytes at the beginning of human pregnancy.人类妊娠初期蜕膜、滋养层与淋巴细胞之间的超微结构关系。
J Reprod Fertil. 1975 Mar;42(3):431-8. doi: 10.1530/jrf.0.0420431.
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引用本文的文献

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Immunologic regulation in pregnancy: from mechanism to therapeutic strategy for immunomodulation.孕期的免疫调节:从机制到免疫调节治疗策略
Clin Dev Immunol. 2012;2012:258391. doi: 10.1155/2012/258391. Epub 2011 Nov 3.
2
Changes in the cell population of the pregnant rodent uterus in relation to the differentiation of granulated metrial gland cells.妊娠啮齿动物子宫细胞群体的变化与颗粒状子宫基质腺细胞的分化关系。
J Anat. 1982 Aug;135(Pt 1):111-8.
3
Immunohistological characterization of lymphoid cell populations in the early human placental bed.
人胎盘床早期淋巴样细胞群的免疫组织学特征
Immunology. 1984 Jun;52(2):349-57.
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Implantation site in normal pregnancy. A study with monoclonal antibodies.正常妊娠时的着床部位。一项使用单克隆抗体的研究。
Am J Pathol. 1985 Jan;118(1):76-84.