Chen Shyi-Jou, Liu Yung-Liang, Sytwu Huey-Kang
Department of Pediatrics, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan.
Clin Dev Immunol. 2012;2012:258391. doi: 10.1155/2012/258391. Epub 2011 Nov 3.
The immunologic interaction between the fetus and the mother is a paradoxical communication that is regulated by fetal antigen presentation and/or by recognition of and reaction to these antigens by the maternal immune system. There have been significant advances in understanding of abnormalities in the maternal-fetal immunologic relationship in the placental bed that can lead to pregnancy disorders. Moreover, immunologic recognition of pregnancy is vital for the maintenance of gestation, and inadequate recognition of fetal antigens may cause abortion. In this paper, we illustrate the complex immunologic aspects of human reproduction in terms of the role of human leukocyte antigen (HLA), immune cells, cytokines and chemokines, and the balance of immunity in pregnancy. In addition, we review the immunologic processes of human reproduction and the current immunologic therapeutic strategies for pathological disorders of pregnancy.
胎儿与母亲之间的免疫相互作用是一种矛盾的交流，它由胎儿抗原呈递和/或母体免疫系统对这些抗原的识别及反应所调节。在理解胎盘床中母胎免疫关系异常（这些异常可导致妊娠疾病）方面已取得了重大进展。此外，对妊娠的免疫识别对于维持妊娠至关重要，而对胎儿抗原的识别不足可能导致流产。在本文中，我们从人类白细胞抗原（HLA）、免疫细胞、细胞因子和趋化因子的作用以及妊娠中的免疫平衡方面阐述了人类生殖复杂的免疫问题。此外，我们还综述了人类生殖的免疫过程以及当前针对妊娠病理疾病的免疫治疗策略。
