Beverley P C, Olabiran Y, Ledermann J A, Bobrow L G, Souhami R L
Imperial Cancer Research Fund, University College and Middlesex School of Medicine, Courtauld Institute of Biochemistry, London.
Br J Cancer Suppl. 1991 Jun;14:10-9.
This chapter presents the results of blind serological studies carried out by workshop participants on 87 monoclonal antibodies (mAbs) supplied to them as a coded panel. Twenty six mAbs had been studied in the first workshop. Participants were asked to carry out immunohistochemical, immunocytological or flow cytometric analysis on a mandatory panel of target tissues or cells. Central computer analysis and other supporting data allowed the assignment of 33 mAbs to seven clusters. Two of the antigens identified have been cloned while two more have been defined as carbohydrate epitopes. The results allow comparison of new mAbs against lung cancer with existing ones and are beginning to provide a description of the antigenic structure of the SCLC cell surface.
本章介绍了研讨会参与者对作为编码组提供给他们的87种单克隆抗体（mAb）进行的盲法血清学研究结果。在第一次研讨会上已对26种mAb进行了研究。要求参与者对一组强制性的靶组织或细胞进行免疫组织化学、免疫细胞化学或流式细胞术分析。中央计算机分析和其他支持数据使得33种mAb被归入7个簇。已克隆出两种鉴定出的抗原，另外两种已被确定为碳水化合物表位。这些结果有助于将针对肺癌的新mAb与现有mAb进行比较，并开始对小细胞肺癌（SCLC）细胞表面的抗原结构进行描述。
