Yenice O, Onal S, Incili B, Temel A, Afşar N, Tanridağ T
Marmara University School of Medicine, Department of Ophthalmology, Istanbul, Turkey.
Eye (Lond). 2007 Feb;21(2):218-23. doi: 10.1038/sj.eye.6702251. Epub 2006 Feb 3.
To study spatial-contrast function and short-wavelength sensitivity deficits in a migraine population with a disease duration of 30 years or less.
In this prospective, cross-sectional study, we evaluated 28 subjects with migraine headache and 15 nonheadache healthy controls. Visual fields were evaluated using the Humphrey Field Analyzer 750i and the 30-2, blue and yellow threshold programme. Contrast sensitivity (CS) was measured at 1.5, 3, 6, 12, and 18 cpd spatial frequencies, using the Functional Acuity Contrast Test (F.A.C.T.). The results of the visual field parameters (mean defect (MD) and pattern standard defect (PSD)) and CS were compared with 15 age-equivalent normal subjects.
Short-wavelength amplitude perimetry (SWAP) parameters and CS scores at all spatial frequencies were significantly altered in the migraine patients when compared with the control subjects. Visual field parameters correlated significantly with contrast sensitivity scores: positively for MD (r=0.39, P=0.01; r=0.43, P=0.005; r=0.56, P=0.0001; r=0.45, P=0.003; r=0.48, P=0.0001) and negatively for PSD (r=-0.45, P=0.003; r=-0.45, P=0.003; r=-0.51, P=0.001; r=-0.53, P=0.0001; and r=-0.67, P=0.0001) at all (1.5, 3, 6,12, and 18 cpd) spatial frequencies, respectively. Migraine duration correlated negatively with MD (r=-0.42, P=0.04) and positively with PSD (r=0.42, P=0.03).
Migraineurs had significantly altered visual field and contrast function at all spatial frequencies to the normal population. These defects share some features with early stages of glaucoma and may relate a possibility for a common vascular disease pathogenesis in these two conditions.
研究病程30年及以内的偏头痛患者的空间对比度功能和短波敏感性缺陷。
在这项前瞻性横断面研究中，我们评估了28名偏头痛患者和15名无头痛的健康对照者。使用Humphrey视野分析仪750i和30 - 2、蓝色和黄色阈值程序评估视野。使用功能性视力对比度测试（F.A.C.T.）在1.5、3、6、12和18 cpd空间频率下测量对比度敏感度（CS）。将视野参数（平均缺损（MD）和模式标准缺损（PSD））和CS的结果与15名年龄匹配的正常受试者进行比较。
与对照受试者相比，偏头痛患者在所有空间频率下的短波振幅视野检查（SWAP）参数和CS评分均有显著改变。视野参数与对比度敏感度评分显著相关：在所有（1.5、3、6、12和18 cpd）空间频率下，MD呈正相关（r = 0.39，P = 0.01；r = 0.43，P = 0.005；r = 0.56，P = 0.0001；r = 0.45，P = 0.003；r = 0.48，P = 0.0001），PSD呈负相关（r = -0.45，P = 0.003；r = -0.45，P = 0.003；r = -0.51，P = 0.001；r = -0.53，P = 0.0001；r = -0.67，P = 0.0001）。偏头痛病程与MD呈负相关（r = -0.42，P = 0.04），与PSD呈正相关（r = 0.42，P = 0.03）。
与正常人群相比，偏头痛患者在所有空间频率下的视野和对比度功能均有显著改变。这些缺陷与青光眼早期阶段有一些共同特征，可能与这两种疾病共有的血管疾病发病机制有关。
