Parkin D M, Srivatanakul P, Khlat M, Chenvidhya D, Chotiwan P, Insiripong S, L'Abbé K A, Wild C P
International Agency for Research on Cancer, Lyon, France.
Int J Cancer. 1991 May 30;48(3):323-8. doi: 10.1002/ijc.2910480302.
Potential risk factors for cholangiocarcinoma were investigated in a case-control study among inhabitants of north-east Thailand, which included 103 cases from 3 hospitals, with age- and sex-matched controls. A clear association with past or present infection with Opisthorchis viverrini, as indicated by raised serum antibodies, was found (o.r. 5.0), and at least two-thirds of cases can be attributed to this cause. The results suggest that males may be at higher risk than females. There was no association with hepatitis B infection, with aflatoxin intake as estimated from albumin adducts in serum or with any particular dietary patterns. Alcohol consumption was very low in the population, and the risk associated with regular drinking was non-significant. Regular users of betel nut-predominantly female-had a high risk (o.r. 6.4), a possible mechanism being through their increased exposure to nitrosamines.
在泰国东北部居民中开展的一项病例对照研究，对胆管癌的潜在风险因素进行了调查。该研究纳入了来自3家医院的103例病例，并设有年龄和性别匹配的对照组。研究发现，血清抗体升高表明过去或现在感染华支睾吸虫与胆管癌存在明确关联（比值比为5.0），至少三分之二的病例可归因于此原因。结果表明，男性可能比女性面临更高的风险。研究未发现与乙肝感染、根据血清中白蛋白加合物估算的黄曲霉毒素摄入量或任何特定饮食模式存在关联。该人群的酒精消费量很低，经常饮酒相关的风险无统计学意义。经常食用槟榔的人群（主要为女性）风险很高（比值比为6.4），一种可能的机制是他们接触亚硝胺的机会增加。
