Srivatanakul P, Parkin D M, Jiang Y Z, Khlat M, Kao-Ian U T, Sontipong S, Wild C
National Cancer Institute, Bangkok, Thailand.
Cancer. 1991 Dec 1;68(11):2411-7. doi: 10.1002/1097-0142(19911201)68:11<2411::aid-cncr2820681114>3.0.co;2-0.
The incidence of the two principle types of liver cancer (hepatocellular carcinoma and cholangiocarcinoma) in five different areas of Thailand was compared with the prevalence of exposure to the main risk factors in samples of the population. Cholangiocarcinoma showed striking variations in incidence, which correlated closely with markers of exposure to the liver fluke, Opisthorchis viverrini. However, there was little geographic variation in incidence of hepatocellular carcinoma or in prevalence of the major risk factors (chronic carriage of hepatitis B virus and exposure to aflatoxin), and apparently there was little relationship between them.
对泰国五个不同地区的两种主要肝癌类型（肝细胞癌和胆管癌）的发病率与人群样本中主要风险因素的暴露率进行了比较。胆管癌的发病率呈现出显著差异，这与肝吸虫华支睾吸虫的暴露标志物密切相关。然而，肝细胞癌的发病率或主要风险因素（乙肝病毒慢性携带和黄曲霉毒素暴露）的流行率几乎没有地理差异，而且它们之间显然几乎没有关联。
