Porta C, Ardizzoni A, Gaudino G, Maio M, Mutti L, Pinto C, Porru S, Puntoni R, Tassi G, Tognon M
IRCCS San Matteo University Hospital, 27100 Pavia, Italy.
Med Lav. 2005 Jul-Aug;96(4):360-9.
Malignant mesothelioma (MMe) is a seemingly uncommon tumour whose incidence has in fact increased steadily and progressively over the last 30 years. Indeed, an actual "epidemic" is expected in the next 20 years, with over 1300 new cases a year till 2020 at least. Despite unquestionable improvement in the diagnostic methods at our disposal and the availability of new treatment strategies, the prognosis of MMe patients remains dramatically poor. For all the above reasons, translational research is the key to success; indeed, ever increasing knowledge of the molecular mechanisms underlying MMe pathogenesis could lead (and is actually leading) to new, hopefully more active, treatment options. To foster discussion among investigators working in this field, and to exchange different viewpoints concerning the newest advances in MMe pathogenesis and treatment, the VII International Mesothelioma Interest Group (IMIG) meeting was held in Brescia (Italy) between 24 and 26 June 2004 in cooperation with the Italian Group for the Study and Therapy of MMe (GIMe). The aim of this report is to summarize the most significant advances in the different disciplines applied to MMe presented and discussed during the IMIG meeting and how these advances will be changing the perspective of patients with MMe.
恶性间皮瘤（MMe）是一种看似不常见的肿瘤，但其发病率在过去30年中实际上一直在稳步且持续上升。事实上，预计在未来20年将出现一场真正的“流行”，至少到2020年每年会有超过1300例新病例。尽管我们现有的诊断方法有了毋庸置疑的改进，且有了新的治疗策略，但MMe患者的预后仍然极差。基于上述所有原因，转化研究是成功的关键；的确，对MMe发病机制背后分子机制的了解不断增加，可能会（实际上也正在）带来新的、有望更有效的治疗选择。为促进该领域研究人员之间的讨论，并就MMe发病机制和治疗的最新进展交流不同观点，第七届国际间皮瘤兴趣小组（IMIG）会议于2004年6月24日至26日在意大利布雷西亚与意大利恶性间皮瘤研究与治疗小组（GIMe）合作举行。本报告的目的是总结在IMIG会议上介绍和讨论的应用于MMe的不同学科的最重要进展，以及这些进展将如何改变MMe患者的前景。
