Cironi Pablo, Alvarez Mercedes, Albericio Fernando
Biomedical Research Institute, Barcelona Scientific Park-University of Barcelona, 08028 Barcelona, Spain.
Mini Rev Med Chem. 2006 Jan;6(1):11-25. doi: 10.2174/138955706775197857.
Solid-phase chemistry, first introduced for peptide synthesis in the 1960's, has become an integral part of organic synthetic methodology. Presented herein is an overview of recent examples of the use of solid-phase in the preparation of non-peptidic natural products and related compounds, encompassing on-resin total syntheses as well as the use of polymer-supported reagents in solution.
固相化学于20世纪60年代首次引入用于肽合成，现已成为有机合成方法中不可或缺的一部分。本文概述了固相在非肽类天然产物及相关化合物制备中的最新应用实例，包括树脂上的全合成以及聚合物负载试剂在溶液中的应用。
