Petit Jean Michel, Masson David, Minello Anne, Duvillard Laurence, Galland Francoise, Verges Bruno, Gambert Philippe, Hillon Patrick
Laboratoire INSERM Unité 498, CHU du Bocage, BP 77908, 21079 Dijon cedex, France.
Mol Genet Metab. 2006 Jun;88(2):196-8. doi: 10.1016/j.ymgme.2005.12.006. Epub 2006 Feb 2.
It has been shown that the HCV-core protein reduces the activity of microsomal triglyceride transfer protein (MTP) and could lead to steatosis in HCV-infected patients. The aim of our study was to investigate the influence of a functional polymorphism in the promoter region of the MTP gene (493G/T) on the development of HCV-related steatosis.
Eighty-six chronic hepatitis C patients were studied to assess: the effects of body mass index, age, HCV genotype, and 493G/T MTP polymorphism on steatosis.
Steatosis was observed in 39 patients (45.3%). The 493G/T MTP polymorphism were not related to the development of steatosis.
The functional G/T MTP polymorphism do not seem to play any role in the development of steatosis in chronic hepatitis C.
研究表明，丙型肝炎病毒核心蛋白可降低微粒体甘油三酯转运蛋白（MTP）的活性，并可能导致丙型肝炎病毒感染患者出现脂肪变性。本研究旨在探讨MTP基因启动子区域功能性多态性（493G/T）对丙型肝炎病毒相关脂肪变性发展的影响。
对86例慢性丙型肝炎患者进行研究，以评估体重指数、年龄、丙型肝炎病毒基因型和493G/T MTP多态性对脂肪变性的影响。
39例患者（45.3%）出现脂肪变性。493G/T MTP多态性与脂肪变性的发展无关。
功能性G/T MTP多态性似乎在慢性丙型肝炎脂肪变性的发展中不起任何作用。
