Systems Biology Program, Centro Nacional de Biotecnología (CNB-CSIC), 28049 Cantoblanco-Madrid, Spain.
Trends Microbiol. 2010 May;18(5):205-14. doi: 10.1016/j.tim.2010.02.003. Epub 2010 Mar 2.
In addition to the sugar phosphotransferase system (sugar PTS) dedicated to carbohydrate uptake, many Gram-negative bacteria possess a so-called nitrogen PTS (PTS(Ntr)). Although fulfilling very different functions, both systems can communicate with each other by phosphate exchange. PTS(Ntr) regulates diverse processes implicated in metabolism of nitrogen and carbon, and is essential for virulence in some bacteria. Additionally, it plays a role in potassium homeostasis by regulating the expression and activity of a high- and a low-affinity K(+) transporter, respectively. In this article, we review recent advances in the understanding of the regulatory roles of PTS(Ntr) in various organisms.
除了专门用于碳水化合物摄取的糖磷酸转移酶系统（糖 PTS）外，许多革兰氏阴性菌还具有所谓的氮磷酸转移酶系统（PTS(Ntr)）。尽管两者的功能非常不同，但它们可以通过磷酸交换进行相互通讯。PTS(Ntr) 调节涉及氮和碳代谢的多种过程，并且对某些细菌的毒力至关重要。此外，它通过分别调节高亲和性和低亲和性 K(+)转运体的表达和活性，在钾稳态中发挥作用。本文综述了近年来对 PTS(Ntr) 在各种生物体中的调节作用的理解的最新进展。
