Mansuy-Schlick Virginie, Tolle Fabrice, Delage-Mourroux Régis, Fraichard Annick, Risold Pierre-Yves, Jouvenot Michèle
Université de Franche-Comté, IFR 133, U.F.R. Sciences et Techniques, Equipe Estrogènes, Expression Génique et Pathologies du Système Nerveux Central, 16 route de Gray, 25030 Besançon cedex, France.
Brain Res. 2006 Feb 16;1073-1074:83-7. doi: 10.1016/j.brainres.2005.11.004. Epub 2006 Feb 3.
GABARAP and GEC1/GABARAPL1 interact with tubulin and GABA(A) receptor and belong to a new protein family. This family includes GATE 16 and LC3, potentially involved in intracellular transport processes. In this study, we combined brain dissection and quantitative real-time reverse transcription polymerase chain reaction to study discriminatively gabarap, gec1/gabarapL1, gate16/gabarapL2, lc3 mRNA distribution in multiple rat brain areas.
GABARAP与GEC1/GABARAPL1与微管蛋白及γ-氨基丁酸A（GABA(A)）受体相互作用，属于一个新的蛋白质家族。该家族包括可能参与细胞内运输过程的GATE 16和LC3。在本研究中，我们结合脑部分离和定量实时逆转录聚合酶链反应，以区分大鼠多个脑区中gabarap、gec1/gabarapL1、gate16/gabarapL2、lc3 mRNA的分布。
