Université de Franche-Comté, Laboratoire de Biochimie, Besançon, France.
Autophagy. 2011 Oct;7(10):1098-107. doi: 10.4161/auto.7.10.15904. Epub 2011 Oct 1.
The GABARAPL1 (GABARAP-LIKE 1) gene was first described as an early estrogen-regulated gene that shares a high sequence homology with GABARAP and is thus a part of the GABARAP family. GABARAPL1, like GABARAP, interacts with the GABAA receptor and tubulin and promotes tubulin polymerization. The GABARAP family members (GABARAP, GABARAPL1 and GABARAPL2) and their close homologs (LC3 and Atg8) are not only involved in the transport of proteins or vesicles but are also implicated in various mechanisms such as autophagy, cell death, cell proliferation and tumor progression. However, despite these similarities, GABARAPL1 displays a complex regulation that is different from that of other GABARAP family members. Moreover, it presents a regulated tissue expression and is the most highly expressed gene among the family in the central nervous system. In this review article, we will outline the specific functions of this protein and also hypothesize about the roles that GABARAPL1 might have in several important biological processes such as cancer or neurodegenerative diseases.
GABARAPL1（GABARAP-LIKE 1）基因最初被描述为一种早期雌激素调节基因，与 GABARAP 具有高度序列同源性，因此是 GABARAP 家族的一部分。GABARAPL1 与 GABARAP 一样，与 GABAA 受体和微管蛋白相互作用，并促进微管蛋白聚合。GABARAP 家族成员（GABARAP、GABARAPL1 和 GABARAPL2）及其密切同源物（LC3 和 Atg8）不仅参与蛋白质或囊泡的运输，而且还涉及各种机制，如自噬、细胞死亡、细胞增殖和肿瘤进展。然而，尽管存在这些相似之处，但 GABARAPL1 的调控非常复杂，与其他 GABARAP 家族成员不同。此外，它表现出受调控的组织表达，并且在中枢神经系统中是该家族中表达水平最高的基因。在这篇综述文章中，我们将概述该蛋白的特定功能，并推测 GABARAPL1 在癌症或神经退行性疾病等重要生物学过程中可能具有的作用。
