Saïdani M, Boutiba I, Ghozzi R, Kammoun A, Ben Redjeb S
Laboratoire de microbiologie, hôpital Charles-Nicolle, 1006 Boulevard du 9-avril, Tunis, Tunisie.
Med Mal Infect. 2006 Mar;36(3):163-6. doi: 10.1016/j.medmal.2005.06.010. Epub 2006 Feb 3.
The authors had for aim to evaluate the place of multi-drug resistant bacteria (MDR) in nosocomial bacteremia.
A retrospective study was carried out at the Microbiology laboratory of Charles Nicolle hospital of Tunis (2001-2003). One hundred and ninety-five isolated MDR [third generation cephalosporin resistant enterobacteria, methicillin-resistant Staphylococcus aureus (MRSA), Acinetobacter baumannii and Pseudomonas aeruginosa resistant to ceftazidime and imipenem]. An automated system was used to detect bloodstream infections. Microorganism identification was performed by conventional methods and antibiotic susceptibilities were determined by the disk diffusion method.
MDR bacteria were resistant to third generation cephalosporins (29%), A. baumannii (24%), P. aeruginosa (24%), and MRSA (10%). ERC3G were resistant to aminosides and fluorquinolones. A. baumannii and P. aeruginosa had high resistance rates. Associated resistance rates in MRSA were moderate.
MDR bacteria are of great concern in our hospital. This situation emphasizes the importance to maintain rigorous measures of hygiene as well as adapted antibiotic prescriptions.
作者旨在评估多重耐药菌（MDR）在医院获得性菌血症中的地位。
在突尼斯查尔斯·尼科勒医院微生物实验室进行了一项回顾性研究（2001 - 2003年）。共195株分离出的多重耐药菌[对第三代头孢菌素耐药的肠杆菌、耐甲氧西林金黄色葡萄球菌（MRSA）、鲍曼不动杆菌以及对头孢他啶和亚胺培南耐药的铜绿假单胞菌]。使用自动化系统检测血流感染。通过传统方法进行微生物鉴定，并采用纸片扩散法测定抗生素敏感性。
多重耐药菌对第三代头孢菌素耐药率为29%，鲍曼不动杆菌为24%，铜绿假单胞菌为24%，耐甲氧西林金黄色葡萄球菌为10%。对第三代头孢菌素耐药的肠杆菌对氨基糖苷类和氟喹诺酮类耐药。鲍曼不动杆菌和铜绿假单胞菌耐药率较高。耐甲氧西林金黄色葡萄球菌的相关耐药率中等。
多重耐药菌在我院令人高度关注。这种情况凸显了维持严格卫生措施以及合理使用抗生素处方的重要性。
