Nansel Tonja R, Riggs Margaret A, Yu Kai-Fun, Andrews William W, Schwebke Jane R, Klebanoff Mark A
Division of Epidemiology, Statistics and Prevention Research, Department of Health and Human Services, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-7510, USA.
Am J Obstet Gynecol. 2006 Feb;194(2):381-6. doi: 10.1016/j.ajog.2005.07.047.
The purpose of this study was to assess the association of psychosocial stress with bacterial vaginosis in a longitudinal sample of nonpregnant women.
A 1-year prospective longitudinal design was used. Nonpregnant women (n = 3614) aged 15 to 44 years were recruited at routine health care visits. Assessments were conducted quarterly for 1 year and included a standardized pelvic examination, an assessment of clinical symptoms, and an extensive self-report interview.
Psychosocial stress was associated with overall prevalence of (adjusted odds ratio, 1.10; 95% CI, 1.01-1.20) and an increased incidence of (adjusted odds ratio, 1.29; 95% CI, 1.12-1.48) bacterial vaginosis. The association between stress and bacterial vaginosis incidence was not changed appreciably by the control for behavioral and demographic characteristics and was magnified (odds ratio, 2.05; 95% CI, 1.15-3.66) in a case-crossover analysis.
Increased psychosocial stress is associated with greater bacterial vaginosis prevalence and incidence independent of other risk factors.
本研究旨在评估非妊娠女性纵向样本中心理社会压力与细菌性阴道病之间的关联。
采用为期1年的前瞻性纵向设计。在常规医疗就诊时招募年龄在15至44岁之间的非妊娠女性（n = 3614）。进行为期1年的季度评估，包括标准化盆腔检查、临床症状评估以及广泛的自我报告访谈。
心理社会压力与细菌性阴道病的总体患病率（校正比值比，1.10；95%置信区间，1.01 - 1.20）及发病率增加（校正比值比，1.29；95%置信区间，1.12 - 1.48）相关。在对行为和人口统计学特征进行控制后，压力与细菌性阴道病发病率之间的关联没有明显变化，并且在病例交叉分析中这种关联被放大（比值比，2.05；95%置信区间，1.15 - 3.66）。
心理社会压力增加与更高的细菌性阴道病患病率和发病率相关，且独立于其他风险因素。
