Sacks David A, Liu Amy I, Wolde-Tsadik Girma, Amini Saeid B, Huston-Presley Larraine, Catalano Patrick M
Department of Obstetrics and Gynecology, Kaiser Foundation Hospital, Bellflower, CA, USA.
Am J Obstet Gynecol. 2006 Feb;194(2):501-7. doi: 10.1016/j.ajog.2005.07.042.
This study was undertaken to determine the proportion of birth weight attributable to glucose concentrations of diabetic mothers.
Data of diabetic women who used insulin were eligible for analysis if the women had been treated during pregnancy for at least 12 weeks, and had recorded at least 50% of 4 daily glucose checks (fasting and 1-hour postprandial) until the last office visit before delivery. The independent association between maternal glucose values and demographics and birth weight percentiles for gestational age and gender were analyzed by multiple regression methods.
Data of 90 diabetic women were analyzed. Only third-trimester glucose concentrations were associated with birth weight. Prepregnancy body mass index was also selected in the models, including second- and/or third-trimester glucose. Together, these variables explained 18% of the variance in birth weight percentiles.
Maternal glycemia during third-trimester and prepregnancy body mass index are independent predictors of birth weight in pregnancies complicated by insulin-requiring gestational or type 2 diabetes.
本研究旨在确定糖尿病母亲的血糖浓度对出生体重的影响比例。
使用胰岛素的糖尿病女性的数据若符合以下条件则可用于分析：这些女性在孕期接受了至少12周的治疗，并且在分娩前的最后一次门诊就诊前记录了至少4次每日血糖检查（空腹和餐后1小时）中的50%。通过多元回归方法分析母亲血糖值与人口统计学以及胎龄和性别的出生体重百分位数之间的独立关联。
分析了90名糖尿病女性的数据。仅孕晚期血糖浓度与出生体重相关。孕前体重指数也被纳入模型，包括孕中期和/或孕晚期血糖。这些变量共同解释了出生体重百分位数中18%的方差。
孕晚期母亲血糖水平和孕前体重指数是患有需胰岛素治疗的妊娠期糖尿病或2型糖尿病的孕妇出生体重的独立预测因素。
