Suppr超能文献

A型肉毒毒素治疗脑瘫中的痉挛性马蹄足。

Botulinum toxin type A for the treatment of the spastic equinus foot in cerebral palsy.

作者信息

Cardoso Eduardo S, Rodrigues Bernardo M, Barroso Marcelo, Menezes Carla J, Lucena Rita S, Nora Daniel B, Melo Ailton

机构信息

Neurology and Epidemiology Division, Federal University of Bahia, Salvador-Bahia, Brazil.

出版信息

Pediatr Neurol. 2006 Feb;34(2):106-9. doi: 10.1016/j.pediatrneurol.2005.08.010.

Abstract

Muscle overactivity, one of the cardinal features of spasticity, is a common sequel of cerebral palsy. In this group of patients spasticity is responsible for several limitations that interfere with gait, causing variable functional disability. Drugs such as baclofen, tizanidine, or benzodiazepines, or even definitive treatments such as orthopedics or neurosurgeries are generally prescribed with uncertain results. The use of botulinum toxin type A has been frequently suggested for the treatment of spastic equinus foot in cerebral palsy, but few studies with adequate methodology support this idea. The present paper reviews and summarizes the data of published double-blind, randomized clinical trials to assess, with a meta-analysis, if botulinum toxin type A is an adequate treatment for spasticity caused by cerebral palsy. The results reveal a statistical superiority of botulinum toxin type A over placebo on gait improvement, tested using the Physician Rating Scale and Video Gait Analysis (Peto odds ratio = 3.99, 95% confidence interval = 2.20-7.22) in patients with spastic equinus foot. The botulinum toxin group also presented better results in the subjective assessment than the placebo group (Peto odds ratio = 3.49, 95% confidence interval = 1.50-8.12). Adverse events were more frequently observed after the use of botulinum toxin type A, but they were considered mild and self-limited.

摘要

肌肉过度活动是痉挛的主要特征之一,是脑瘫常见的后遗症。在这类患者中,痉挛导致了多种限制,干扰了步态,造成了不同程度的功能残疾。通常会使用巴氯芬、替扎尼定或苯二氮䓬类药物,甚至是骨科手术或神经外科手术等确定性治疗方法,但效果往往不确定。A型肉毒毒素常被建议用于治疗脑瘫患者的痉挛性马蹄足,但很少有方法得当的研究支持这一观点。本文回顾并总结了已发表的双盲、随机临床试验数据,通过荟萃分析评估A型肉毒毒素是否是治疗脑瘫所致痉挛的合适方法。结果显示,在使用医师评定量表和视频步态分析进行测试时,A型肉毒毒素在改善痉挛性马蹄足患者的步态方面比安慰剂具有统计学优势(佩托优势比=3.99,95%置信区间=2.20-7.22)。在主观评估中,肉毒毒素组的结果也优于安慰剂组(佩托优势比=3.49,95%置信区间=1.50-8.12)。使用A型肉毒毒素后更频繁地观察到不良事件,但这些事件被认为是轻微的且具有自限性。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验