Aoyagi Yasuo
Kagawa Nutrition University, 3-9-21 Chiyoda, Sakado, Saitama 350-0288, Japan.
Phytochemistry. 2006 Mar;67(6):618-21. doi: 10.1016/j.phytochem.2005.12.022. Epub 2006 Feb 3.
A compound that inhibited angiotensin-I converting enzyme (ACE) activity was isolated from buckwheat powder. This compound is thought to be the hydroxy derivative of nicotianamine and its chemical structure is 2''-hydroxynicotianamine. This compound showed a very high inhibitory activity toward ACE, and the IC(50) was 0.08 microM. Only this hydroxy analog was found in buckwheat powder, at about 30 mg/100g, and no nicotianamine was detected. However, nicotianamine was detected in the buckwheat plant body. 2''-hydroxynicotianamine was also found in other polygonaceous plants.
从荞麦粉中分离出一种抑制血管紧张素-I转换酶（ACE）活性的化合物。该化合物被认为是烟酰胺的羟基衍生物，其化学结构为2''-羟基烟酰胺。该化合物对ACE表现出非常高的抑制活性，IC(50)为0.08微摩尔。在荞麦粉中仅发现这种羟基类似物，含量约为30毫克/100克，未检测到烟酰胺。然而，在荞麦植株体中检测到了烟酰胺。在其他蓼科植物中也发现了2''-羟基烟酰胺。
