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苋属植物作为抗高血压肽的来源。

Amaranth as a Source of Antihypertensive Peptides.

作者信息

Nardo Agustina E, Suárez Santiago, Quiroga Alejandra V, Añón María Cristina

机构信息

Centro de Investigación y Desarrollo en Criotecnología de Alimentos (CIDCA), Facultad de Ciencias Exactas, Universidad Nacional de La Plata (UNLP), Comisión de Investigaciones Científicas (CIC-PBA) and Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET- CCT La Plata), La Plata, Argentina.

出版信息

Front Plant Sci. 2020 Sep 25;11:578631. doi: 10.3389/fpls.2020.578631. eCollection 2020.

DOI:10.3389/fpls.2020.578631
PMID:33101347
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7546275/
Abstract

Amaranth is an ancestral crop used by pre-Columbian cultures for 6000 to 8000 years. Its grains have a relevant chemical composition not only from a nutritional point of view but also due to the contribution of components with good techno-functional properties and important potential as bioactive compounds. Numerous studies have shown that amaranth storage proteins possess encrypted sequences that, once released, exhibit different physiological activities. One of the most studied is antihypertensive activity. This review summarizes the progress made over the last years (2008-2020) related to this topic. Studies related to inhibition of different enzymes of the Renin-Angiotensin-Aldosterone system, in particular Angiotensin Converting Enzyme (ACE) and Renin, as well as those referring to potential modulation mechanisms of tissue or local Renin-Angiotensin-Aldosterone system, are analyzed, including , , , and assays. Furthermore, the potential use of these bioactive peptides or products containing them, in the elaboration of functional food matrices is discussed. Finally, the most relevant conclusions and future requirements in research and development of food products are presented.

摘要

苋属植物是一种古老的作物，在哥伦布发现美洲大陆之前，前哥伦布时期的文化已使用了6000至8000年。其籽粒不仅从营养角度来看具有相关的化学成分，而且还得益于具有良好技术功能特性的成分以及作为生物活性化合物的重要潜力。众多研究表明，苋属植物贮藏蛋白拥有经加密的序列，一旦释放，便会展现出不同的生理活性。其中研究最多的一种是降压活性。本综述总结了过去几年（2008 - 2020年）在该主题上取得的进展。分析了与抑制肾素 - 血管紧张素 - 醛固酮系统的不同酶，特别是血管紧张素转换酶（ACE）和肾素有关的研究，以及那些涉及组织或局部肾素 - 血管紧张素 - 醛固酮系统潜在调节机制的研究，包括 、 、 和 测定法。此外，还讨论了这些生物活性肽或含有它们的产品在功能性食品基质制备中的潜在用途。最后，给出了食品研究与开发中最相关的结论以及未来需求。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c439/7546275/b6692f0ce299/fpls-11-578631-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c439/7546275/798783547075/fpls-11-578631-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c439/7546275/fc767026c4d7/fpls-11-578631-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c439/7546275/b6692f0ce299/fpls-11-578631-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c439/7546275/798783547075/fpls-11-578631-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c439/7546275/fc767026c4d7/fpls-11-578631-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c439/7546275/b6692f0ce299/fpls-11-578631-g003.jpg

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