Saito Shinichiro, Takeshita Masao, Tomonobu Kazuichi, Kudo Naoto, Shiiba Daisuke, Hase Tadashi, Tokimitsu Ichiro, Yasukawa Takuji
Health Care Products Research Laboratories No. 1, Kao Corporation, Tokyo, Japan.
Nutrition. 2006 Feb;22(2):174-8. doi: 10.1016/j.nut.2005.05.013.
The objective of this study was to investigate the effective dose of plant sterol ester (PSE)-enriched diacylglycerol (DAG) oil for healthy subjects with mild hypercholesterolemia.
A randomized, placebo-controlled, double-blind, parallel study was performed in patients with mild hypercholesterolemia; 0.0, 0.3, 0.4, and 0.5 g of PSE was dissolved in 15 g of a DAG-containing mayonnaise-type product; and 15 g/d of the product was administered 4 wk.
Total serum cholesterol levels were significantly decreased as a result of the ingestion of at least 0.4 g/d of PSE, and serum low-density lipoprotein cholesterol levels were significantly decreased by the ingestion of at least 0.3 g/d of PSE.
Daily ingestion of 15 g of DAG plus mayonnaise containing at least 0.4 g/d of PSE for 4 wk may significantly decrease cholesterol.
