Saito Shinichiro, Tomonobu Kazuichi, Kudo Naoto, Shiiba Daisuke, Hase Tadashi, Tokimitsu Ichiro
Health Care Products Research Laboratories No. 1, Kao Corporation, Tokyo, Japan.
Ann Nutr Metab. 2006;50(4):372-9. doi: 10.1159/000094302. Epub 2006 Jun 28.
Diacylglycerol (DAG) suppresses the postprandial increase in serum triglycerides, and has antiobesity effects. On the other hand, plant sterol esters (PSE) lower serum cholesterol levels in hypercholesterolemia. Thus, DAG-containing PSE (PSE/DAG) would be expected to maintain an appropriate serum cholesterol level and decrease the risk of arteriosclerotic disorders. Several recent studies, however, report negative effects of PSE on serum fat-soluble (pro)vitamin levels. The objective of this study was to investigate the effect of PSE/DAG on serum retinol, beta-carotene, and alpha-tocopherol levels using a threefold excess of the effective dose obtained in our previous study.
A randomized placebo-controlled double-blind parallel study was performed in healthy and mildly hypercholesterolemic subjects, in which the subjects ingested 1.2 g PSE/30 g DAG for 2 weeks in the form of mayonnaise-type products. Triacylglycerol (TAG) mayonnaise was used as a control.
There were no subjective adverse effects or changes in serum retinol, alpha-tocopherol, and beta-carotene levels, abdominal symptoms, hematologic values, or blood biochemical values.
Ingestion of a threefold excess of PSE/DAG for 2 weeks had no adverse effects compared to ingestion of conventional TAG mayonnaise.
二酰基甘油（DAG）可抑制餐后血清甘油三酯的升高，并具有抗肥胖作用。另一方面，植物甾醇酯（PSE）可降低高胆固醇血症患者的血清胆固醇水平。因此，含DAG的PSE（PSE/DAG）有望维持适当的血清胆固醇水平，并降低动脉粥样硬化疾病的风险。然而，最近的几项研究报告了PSE对血清脂溶性（原）维生素水平的负面影响。本研究的目的是使用我们先前研究中获得的有效剂量的三倍过量剂量，研究PSE/DAG对血清视黄醇、β-胡萝卜素和α-生育酚水平的影响。
在健康和轻度高胆固醇血症受试者中进行了一项随机安慰剂对照双盲平行研究，受试者以蛋黄酱型产品的形式摄入1.2 g PSE/30 g DAG，为期2周。使用三酰甘油（TAG）蛋黄酱作为对照。
血清视黄醇、α-生育酚和β-胡萝卜素水平、腹部症状、血液学值或血液生化值均无主观不良反应或变化。
与摄入传统TAG蛋黄酱相比，过量摄入三倍剂量的PSE/DAG 2周没有不良反应。
