水蓑衣水提取物可改善四氧嘧啶诱导的糖尿病大鼠组织中的抗氧化状态。

Enicostemma littorale Blume aqueous extract improves the antioxidant status in alloxan-induced diabetic rat tissues.

作者信息

Prince Ponnaian Stanley Mainzen, Srinivasan Mohan

机构信息

Department of Biochemistry, Annamalai University, Annamalainagar, Tamil Nadu, India 608 002.

出版信息

Acta Pol Pharm. 2005 Sep-Oct;62(5):363-7.

PMID:16459485

Abstract

This study investigates the effect of oral administration of an aqueous Enicostemma littorale whole plant extract on antioxidant defense in alloxan-induced diabetes in rats. A significant increase in blood glucose and increased concentration of thiobarbituric acid reactive substances (TBARS) and hydroperoxides (HP) in liver, kidney and pancreas were observed in alloxan diabetic rats. Decreased concentration of reduced glutathione (GSH) and decreased activities of superoxide dismutase (SOD), catalase and glutathione peroxidase (GPx) were also observed in these tissues of diabetic rats. Oral administration of aqueous E. littorale whole plant extract (1 and 2 g/kg) to diabetic rats daily for 45 days significantly decreased blood glucose, TBARS, HP and increased GSH, SOD, catalase and GPx. E. littorale extract at the dose of 2 g/kg was more effective than 1 g/kg. Insulin (6 units/kg) administration to diabetic rats for 45 days brought back all the parameters to near normal status.

摘要

本研究调查了口服海滨水蓑衣全株水提取物对四氧嘧啶诱导的糖尿病大鼠抗氧化防御的影响。在四氧嘧啶诱导的糖尿病大鼠中，观察到血糖显著升高，肝脏、肾脏和胰腺中硫代巴比妥酸反应性物质（TBARS）和氢过氧化物（HP）的浓度增加。在糖尿病大鼠的这些组织中还观察到还原型谷胱甘肽（GSH）浓度降低，超氧化物歧化酶（SOD）、过氧化氢酶和谷胱甘肽过氧化物酶（GPx）的活性降低。每天给糖尿病大鼠口服海滨水蓑衣全株水提取物（1和2 g/kg），持续45天，可显著降低血糖、TBARS、HP，并增加GSH、SOD、过氧化氢酶和GPx。2 g/kg剂量的海滨水蓑衣提取物比1 g/kg更有效。给糖尿病大鼠注射胰岛素（6单位/kg），持续45天，可使所有参数恢复到接近正常状态。