DeSesso J M, Watson R E
Mitretek Systems, 3150 Fairview Park Drive, Falls Church, VA 22042, USA.
Hum Exp Toxicol. 2006 Jan;25(1):7-10. doi: 10.1191/0960327106ht578oa.
When conducting risk assessments, the US Environmental Protection Agency (EPA) does not currently consider the beneficial effects from exposure to concentrations of agents below the no observed adverse effect level (NOAEL). If such benefits were observed, and if the beneficial and toxicological mechanisms of action were identical, this would probably be represented as a 'j-shaped' hormetic dose-response curve. If such data are available, they should be considered when assigning uncertainty factors for safe exposure calculations. However, when such data are not readily available, as is likely the case when the mechanism of action of the benefit differs from that of toxicity, current US EPA methods appear adequate.
在进行风险评估时，美国环境保护局（EPA）目前并未考虑接触低于未观察到有害作用水平（NOAEL）的物质浓度所产生的有益影响。如果观察到此类益处，并且如果有益作用和毒理学作用机制相同，这可能会表现为“J形”的 hormetic 剂量反应曲线。如果有此类数据，在为安全暴露计算确定不确定性因素时应予以考虑。然而，当此类数据不易获取时，比如有益作用机制与毒性作用机制不同的情况很可能就是如此，美国 EPA 当前的方法似乎是足够的。
