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重度和非重度饮酒场合、全因死亡率和心血管疾病死亡率及住院情况:一项针对低消费水平人群的随访研究

Heavy and nonheavy drinking occasions, all-cause and cardiovascular mortality and hospitalizations: a follow-up study in a population with a low consumption level.

作者信息

Makelä Pia, Paljärvi Tapio, Poikolainen Kari

机构信息

Alcohol and Drug Research Group, STAKES, P.O. Box 220, 00531 Helsinki, Finland.

出版信息

J Stud Alcohol. 2005 Nov;66(6):722-8. doi: 10.15288/jsa.2005.66.722.

DOI:10.15288/jsa.2005.66.722
PMID:16459933
Abstract

OBJECTIVE

The purpose of this study was to separate the effects of heavy and nonheavy episodic drinking on mortality and hospitalizations from ischemic heart disease (IHD) and other cardiovascular disease (OCVD) and on all-cause mortality.

METHOD

The respondents in Finnish drinking habit surveys in 1969, 1976 and 1984 (N = 6,394) were followed up for mortality and hospitalizations. There were 1,144 total deaths from all causes, 854 hospitalizations or deaths from IHD and 1,270 from OCVD. The main variables included total volume of consumption and total volume divided into volume consumed on heavy drinking occasions and nonheavy drinking occasions. Four alternative measures of heavy episodic drinking (HED) were also used.

RESULTS

Among males, the total volume of consumption showed a protective effect against IHD. A high volume consumed on light drinking occasions was associated with a decreased risk of IHD (hazard ratio [HR] = 0.56, confidence interval [CI]: 0.34-0.92) and an increased risk of OCVD (HR = 1.48, CI: 1.00-2.18). A high volume consumed on heavy drinking occasions was associated with an increased risk of all-cause mortality (HR = 1.34, CI: 1.04-1.73). Among females, a protective effect of total and non-HED volume against all-cause mortality and non-HED volume against IHD was observed.

CONCLUSIONS

The findings contribute to the cumulating evidence that drinking pattern matters. Moderate drinking is associated with a lower risk of IHD, whereas drinking in a heavy episodic manner (often referred to as "binge drinking") is not. The results underline the importance of considering, in addition to the volume of consumption, the pattern of drinking in epidemiological studies.

摘要

目的

本研究旨在区分大量与非大量偶发性饮酒对缺血性心脏病(IHD)和其他心血管疾病(OCVD)死亡率及住院率以及全因死亡率的影响。

方法

对1969年、1976年和1984年芬兰饮酒习惯调查中的受访者(N = 6394)进行死亡率和住院情况随访。全因死亡共计1144例,IHD导致的住院或死亡854例,OCVD导致的1270例。主要变量包括饮酒总量,以及分为大量饮酒场合和非大量饮酒场合的饮酒量。还使用了四种大量偶发性饮酒(HED)的替代测量方法。

结果

在男性中,饮酒总量对IHD有保护作用。非大量饮酒场合的高饮酒量与IHD风险降低相关(风险比[HR]=0.56,置信区间[CI]:0.34 - 0.92),与OCVD风险增加相关(HR = 1.48,CI:1.00 - 2.18)。大量饮酒场合的高饮酒量与全因死亡率增加相关(HR = 1.34,CI:1.04 - 1.73)。在女性中,观察到饮酒总量和非HED饮酒量对全因死亡率有保护作用,非HED饮酒量对IHD有保护作用。

结论

这些发现为饮酒模式很重要这一不断积累的证据做出了贡献。适度饮酒与较低的IHD风险相关,而大量偶发性饮酒(通常称为“暴饮”)则不然。结果强调了在流行病学研究中除饮酒量外还需考虑饮酒模式的重要性。

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