Abbondanzo S L, Sulak L E
Department of Pathology, University of Texas Health Science Center, San Antonio.
Cancer. 1991 Jun 15;67(12):3117-22. doi: 10.1002/1097-0142(19910615)67:12<3117::aid-cncr2820671229>3.0.co;2-5.
The case is described of a 62-year-old man with a 10-year history of hairy cell leukemia (HCL) who subsequently had a large-cell anaplastic or so-called Ki-1-positive lymphoma. Immunocytochemical staining of the lymphomatous node revealed positivity for Ki-1 (CD30) and epithelial membrane antigen in the tumor cells, and flow cytometric analysis showed simultaneous expression of Leu M5 (CD11c) and Leu 14 (CD22). Although HCL has been reported to coexist with both Hodgkin's disease and non-Hodgkin's lymphoma, the authors believe this is the first case in which a Ki-1-positive lymphoma developed in a patient with HCL. The clinicopathologic and immunologic features of both entities are discussed, as is the association of HCL with other neoplasms.
本文描述了一名62岁男性患者，其有10年毛细胞白血病（HCL）病史，随后发生了大细胞间变性或所谓的Ki-1阳性淋巴瘤。对淋巴瘤结节进行免疫细胞化学染色显示肿瘤细胞中Ki-1（CD30）和上皮膜抗原呈阳性，流式细胞术分析显示同时表达Leu M5（CD11c）和Leu 14（CD22）。虽然已有报道HCL可与霍奇金病和非霍奇金淋巴瘤共存，但作者认为这是首例在HCL患者中发生Ki-1阳性淋巴瘤的病例。文中讨论了这两种疾病的临床病理和免疫学特征，以及HCL与其他肿瘤的关联。
