在加蓬野生黑猩猩（Pan troglodytes troglodytes）粪便样本中鉴定乙肝病毒基因组。

Identification of hepatitis B virus genome in faecal sample from wild living chimpanzee (Pan troglodytes troglodytes) in Gabon.

作者信息

Makuwa M, Souquière S, Clifford S L, Mouinga-Ondeme A, Bawe-Johnson M, Wickings E J, Latour S, Simon F, Roques P

机构信息

Laboratoire de Rétrovirologie, Centre International de Recherches Médicales, Franceville, Gabon.

出版信息

J Clin Virol. 2005 Dec;34 Suppl 1:S83-8. doi: 10.1016/s1386-6532(05)80016-2.

DOI:10.1016/s1386-6532(05)80016-2

PMID:16461230

Abstract

Non-invasive faecal sampling in the equatorial forest in Gabon allowed the first identification of the hepatitis B virus (HBV-Ch(RC170)) genome in samples collected from wild chimpanzees (Pan troglodytes troglodytes). The HBV-Ch(RCl70)sequence clustered with 100% bootstrap support with previous viral sequences obtained from Pan troglodytes subspecies. This is the first evidence of HBV infection in wild apes and confirms that the HBV-like strains thus far characterized in captive apes are directly related to those circulating in the wild.

摘要

在加蓬赤道森林中进行的非侵入性粪便采样，首次在从野生黑猩猩（Pan troglodytes troglodytes）采集的样本中鉴定出乙肝病毒（HBV-Ch(RC170)）基因组。HBV-Ch(RCl70)序列与之前从黑猩猩亚种获得的病毒序列以100%的自展支持率聚类。这是野生猿类感染乙肝病毒的首个证据，并证实了迄今为止在圈养猿类中鉴定出的类乙肝病毒株与野生环境中传播的病毒株直接相关。