环肽轮烷
Rotaxanes of cyclic peptides.
作者信息
Aucagne Vincent, Leigh David A, Lock Julia S, Thomson Andrew R
机构信息
University of Edinburgh, School of Chemistry, The King's Buildings, West Mains Road, Edinburgh EH9 3JJ, UK.
出版信息
J Am Chem Soc. 2006 Feb 15;128(6):1784-5. doi: 10.1021/ja057206q.
PMID:16464065
Abstract
The synthesis of rotaxanes derived from the synthetic peptide macrocycles cyclo(l-ProGly)4 and cyclo(l-ProGly)5 and diammonium threads is described. [2]Rotaxanes are formed in good yields (56-63%), despite the disruption of internal amide-amide hydrogen bonding in the macrocycles.
摘要
本文描述了由合成肽大环化合物环（L-脯氨酸-甘氨酸）4和环（L-脯氨酸-甘氨酸）5与二铵线衍生的轮烷的合成。尽管大环化合物内部的酰胺-酰胺氢键被破坏，但轮烷仍能以良好的产率（56-63%）形成。
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