机械互锁寡核苷酸的 AT-CuAAC 合成。
AT-CuAAC Synthesis of Mechanically Interlocked Oligonucleotides.
机构信息
Chemistry, University of Southampton, Highfield, Southampton, SO17 1BJ, U.K.
ATDBio Ltd, School of Chemistry, University of Southampton, Highfield, Southampton, SO17 1BJ, U.K.
出版信息
J Am Chem Soc. 2020 Apr 1;142(13):5985-5990. doi: 10.1021/jacs.0c01670. Epub 2020 Mar 20.
Abstract
We present a simple strategy for the synthesis of main chain oligonucleotide rotaxanes with precise control over the position of the macrocycle. The novel DNA-based rotaxanes were analyzed to assess the effect of the mechanical bond on their properties.
摘要
我们提出了一种简单的策略，用于合成主链寡核苷酸轮烷，可精确控制大环的位置。对新型基于 DNA 的轮烷进行了分析，以评估机械键对其性质的影响。
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