N-硫醇化2-恶唑烷酮类：一类针对耐甲氧西林金黄色葡萄球菌和炭疽芽孢杆菌的新型抗菌剂。
N-thiolated 2-oxazolidinones: a new family of antibacterial agents for methicillin-resistant Staphylococcus aureus and Bacillus anthracis.
作者信息
Mishra Rajesh Kumar, Revell Kevin D, Coates Cristina M, Turos Edward, Dickey Sonja, Lim Daniel V
机构信息
Department of Chemistry, 4202 East Fowler Avenue, University of South Florida, Tampa, FL 33620, USA.
出版信息
Bioorg Med Chem Lett. 2006 Apr 15;16(8):2081-3. doi: 10.1016/j.bmcl.2006.01.058. Epub 2006 Feb 7.
In this report, we describe a new family of N-thiolated 2-oxazolidinones having antibacterial activity against methicillin-resistant Staphylococcus aureus and Bacillus anthracis. The effect of ring substituents and stereochemistry on antibacterial activity of these oxazolidinones closely parallels that previously reported for N-thiolated beta-lactam antibiotics.
在本报告中，我们描述了一类新型的N-硫醇化2-恶唑烷酮，它们对耐甲氧西林金黄色葡萄球菌和炭疽芽孢杆菌具有抗菌活性。这些恶唑烷酮的环取代基和立体化学对抗菌活性的影响与先前报道的N-硫醇化β-内酰胺抗生素的情况极为相似。
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