易于获得 Evans 的恶唑烷酮。新型 2-恶唑烷酮衍生物的立体选择性合成和抗菌活性。

Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Belo Horizonte-MG 31270-901, Brazil.

Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, Viçosa-MG 36570-000, Brazil.

Molecules. 2014 Jun 6;19(6):7429-39. doi: 10.3390/molecules19067429.

An interesting new approach was developed for the synthesis of Evans' chiral auxiliaries with excellent yields. In turn, another new stereoselective and efficient strategy has also allowed for the preparation of a 2-oxazolidinone derivative in 34% overall yield from the Morita-Baylis-Hillman adduct. The antibacterial activity of this oxazolidinone was tested against Staphylococcus aureus strains isolated from animals with mastitis infections.

一种有趣的新方法被开发用于 Evans 手性辅剂的合成，产率优异。反过来，另一种新的立体选择性和高效策略也允许从 Morita-Baylis-Hillman 加成物以 34%的总收率制备 2-噁唑烷酮衍生物。该噁唑烷酮的抗菌活性已针对从患有乳腺炎感染的动物中分离出的金黄色葡萄球菌菌株进行了测试。