Jiang Xiong-Jie, Huang Jian-Dong, Zhu Yu-Jiao, Tang Fen-Xiang, Ng Dennis K P, Sun Jian-Cheng
College of Chemistry and Chemical Engineering, Institute of Research on Functional Materials, Fuzhou University, Fuzhou 350002, China.
Bioorg Med Chem Lett. 2006 May 1;16(9):2450-3. doi: 10.1016/j.bmcl.2006.01.075. Epub 2006 Feb 7.
Two novel axially substituted phthalocyanines, namely bis(4-(4-acetylpiperazine)phenoxy)phthalocyaninatosilicon (IV) (1) and its N-methylated derivative 2, have been synthesized. The dicationic phthalocyanine 2 is non-aggregated in water and exhibits good photophysical properties. The non-covalent BSA conjugates of these compounds have also been prepared. Compound 2 and the conjugate 2-BSA show extremely high photodynamic activities toward B16 melanoma cancer cell lines. The corresponding 50% growth-inhibitory (IC50) ratios are 33 and 38 nM, respectively.
两种新型轴向取代的酞菁化合物，即双（4-（4-乙酰基哌嗪）苯氧基）酞菁硅（IV）（1）及其N-甲基化衍生物2，已被合成。二价阳离子酞菁2在水中不聚集，并表现出良好的光物理性质。这些化合物的非共价牛血清白蛋白（BSA）缀合物也已制备出来。化合物2和缀合物2-BSA对B16黑色素瘤癌细胞系表现出极高的光动力活性。相应的50%生长抑制（IC50）率分别为33和38 nM。
