[一种用于临床评估胃液蛋白水解活性和酸度的快速放射性核素方法]

[A rapid radionuclide method for clinical assessment of gastric juice proteolytic activity and acidity].

作者信息

Popova L V, Sergienko V B, Amirov N Sh

出版信息

Ter Arkh. 1991;63(2):30-4.

Abstract

A new method for radionuclide measurement of gastric juice proteolytic activity (GJPA) is described. GJPA is determined according to the time of dissolution of the protein capsule filled with 99mTc-pertechnetate solution. In vitro experiments made with 342 samples of gastric juice revealed a correlation (p1 less than 0.01) between the time of dissolution of the 99mTc-pertechnetate capsule and proteolytic activity measured according to Metta's method. No correlation was established between GJPA (measured by Metta's method and by radionuclide method) and gastric juice acidity (p greater than 0.05). In 63 patients examined, the time of capsule dissolution was 15 to 18 minutes with GJPA being normal, 8 to 14 minutes (p less than 0.01) with elevated parameters of GJPA, and 19 to 37 minutes (p less than 0.01) with GJPA being reduced. The given method is a physiological one, sufficiently precise and can be recommended for a screening analysis of GJPA.

摘要

本文描述了一种测量胃液蛋白水解活性（GJPA）的放射性核素新方法。GJPA是根据填充有高锝[99mTc]酸盐溶液的蛋白胶囊的溶解时间来测定的。对342份胃液样本进行的体外实验显示，高锝[99mTc]酸盐胶囊的溶解时间与根据梅塔方法测定的蛋白水解活性之间存在相关性（p1<0.01）。GJPA（通过梅塔方法和放射性核素方法测量）与胃液酸度之间未建立相关性（p>0.05）。在63例接受检查的患者中，胶囊溶解时间在GJPA正常时为15至18分钟，GJPA参数升高时为8至14分钟（p<0.01），GJPA降低时为19至37分钟（p<0.01）。该方法是一种生理学方法，足够精确，可推荐用于GJPA的筛查分析。