Ermilov V B, Aleksandrova V A, Baranova L N, Ponomareva T N, Baranovskiĭ A V, Mos'pan O O, Chernomordikov V G, Likhachev A Ia
Vopr Onkol. 1993;39(4-6):189-92.
The study involved two groups of patients aged 6-14 and 40-60 years, and identification of different conditions of gastric mucosa. The study has established a correlation between the nitrosation activity and acidity of gastric juice and the pathological condition of the gastric mucosa. Enhanced nitrosation activity was observed in samples with a pH under 4.0. That activity was at its lowest in cases of normal gastric mucosa, and at its peak--in high-acidity superficial and erosive gastritis. In cases of superficial gastritis with similar levels of acidity, the nitrosation activity of gastric juice for different amines in children was 2-4 times that in adults. The difference in nitrosation levels for different amines tended to diminish with the decrease in the basicity of the amine in question. A linear correlation was observed between the free-radical activity of gastric juice samples and nitrosation activity (correlation coefficient, k = 0.72).
该研究涉及两组年龄分别为6至14岁和40至60岁的患者，并对胃黏膜的不同状况进行了鉴定。该研究已证实胃液的亚硝化活性和酸度与胃黏膜的病理状况之间存在关联。在pH值低于4.0的样本中观察到亚硝化活性增强。该活性在正常胃黏膜病例中最低，而在高酸性浅表性和糜烂性胃炎中最高。在酸度水平相似的浅表性胃炎病例中，儿童胃液对不同胺类的亚硝化活性是成人的2至4倍。不同胺类的亚硝化水平差异倾向于随着所讨论胺类碱性的降低而减小。观察到胃液样本的自由基活性与亚硝化活性之间存在线性相关性（相关系数，k = 0.72）。
