Massewitsch C, Gorschkow W
Acta Hepatogastroenterol (Stuttg). 1977 Dec;24(6):452-5.
A semi-quantitative method for the analysis of the proteolytic activity of the gastric juice is described. The method is based on the measurement of "lengths" of digested chicken egg-white in fenestrated chlorvinyl tubes. Each tube remained in the stomach of the test subject for 12 hours, either during the day or during the night. During the night, the proteolytic activity of the gastric juice was 30% higher than during the day. A one-week ulcer therapy with atropine and Vikalin (Roter) led to a significant (p less than 0.01) reduction of the nocturnal proteolytic activity. The anticholinergic Chlososil (0.08 g) administered in the evening reduced the proteolytic potential during the night to the level seen during the day. In patients with duodenal and gastric ulcers, the drop in proteolytic activity during ulcer therapy was inversely proportional to the level of the acid output.
本文描述了一种用于分析胃液蛋白水解活性的半定量方法。该方法基于对有孔氯乙烯管中消化的鸡蛋白“长度”的测量。每个管子在白天或夜间都在受试对象的胃中放置12小时。夜间，胃液的蛋白水解活性比白天高30%。用阿托品和维卡林（罗特）进行为期一周的溃疡治疗导致夜间蛋白水解活性显著降低（p<0.01）。晚上服用抗胆碱能药物克洛索西尔（0.08 g）可将夜间的蛋白水解潜能降低至白天的水平。在十二指肠溃疡和胃溃疡患者中，溃疡治疗期间蛋白水解活性的下降与胃酸分泌水平成反比。
