Amuchou Singh Soraisham, Singhal Nalini
Department of Pediatrics, University of Calgary, Alberta, Canada.
Indian Pediatr. 2006 Jan;43(1):20-5.
To study the correlation and agreement between end-tidal carbon dioxide (EtCO2) and arterial carbon dioxide (PaCO(2)) in ventilated extremely low birth weight (ELBW) infants in the first week of life.
Retrospective chart review of all ELBW (<1,000 g) infants admitted to a level III NICU from January 2003 to December 2003. Data collected included demographic details and simultaneous EtCO(2) (mainstream capnography) and arterial blood gas values (pH, PaCO(2), PaO(2)).
The correlation coefficient, degree of bias with 95% confidence interval between the EtCO(2) and PaCO(2).
There were 754 end-tidal and arterial CO(2) pairs from 31 ELBW infants (21 male and 10 female). The overall EtCO(2) values were significantly lower than PaCO(2) value. In only 89/754(11.8%) pairs, the EtCO(2) was higher than the PaCO(2). The overall bias was 5.6 +/- 6.9 mmHg (95% C.I. 5.11-6.09). The intraclass correlation coefficient was 0.81. Using EtCO2 ranges of 30 to 50 mmHg, the capnographic method was able to identify 84% of instances where PaCO(2) was between 35 (<35 = hypocarbia) and 55 mmHg (>55= hypercapnia).
There is good correlation and agreement between end-tidal CO(2) and arterial CO(2) in ELBW infants in the EtCO(2) range 30-50 mmHg. End-tidal CO(2) monitoring can be helpful in trending or for screening abnormal PaCO(2) values in ELBW infants in first week of life.
研究出生体重极低（ELBW）的通气新生儿出生后第一周内呼气末二氧化碳（EtCO2）与动脉二氧化碳（PaCO₂）之间的相关性和一致性。
对2003年1月至2003年 December收治于三级新生儿重症监护病房（NICU）的所有出生体重极低（<1000g）的婴儿进行回顾性病历审查。收集的数据包括人口统计学细节以及同步的EtCO₂（主流二氧化碳图）和动脉血气值（pH、PaCO₂、PaO₂）。
31例出生体重极低的婴儿（21例男婴和10例女婴）有754对呼气末和动脉二氧化碳数据。总体EtCO₂值显著低于PaCO₂值。仅在89/754（11.8%）对数据中，EtCO₂高于PaCO₂。总体偏差为5.6±6.9 mmHg（95%置信区间5.11 - 6.09）。组内相关系数为0.81。使用30至50 mmHg的EtCO₂范围，二氧化碳图法能够识别84%的PaCO₂在35（<35 = 低碳酸血症）至55 mmHg（>55 = 高碳酸血症）之间的情况。
出生体重极低的婴儿在EtCO₂范围30 - 50 mmHg时，呼气末二氧化碳与动脉二氧化碳之间存在良好的相关性和一致性。呼气末二氧化碳监测有助于追踪出生体重极低的婴儿出生后第一周内的PaCO₂值变化趋势或筛查异常值。
