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相似文献

1
Synthetic inositol 1,3,4,5-tetrakisphosphate analogues.合成肌醇1,3,4,5-四磷酸类似物。
Biochem J. 1991 Jun 1;276 ( Pt 2)(Pt 2):333-6. doi: 10.1042/bj2760333.
2
A salt-activated inositol 1,3,4,5-tetrakisphosphate 3-phosphatase at the inner surface of the human erythrocyte membrane.人红细胞膜内表面的一种盐激活的肌醇1,3,4,5-四磷酸3-磷酸酶。
Proc Biol Sci. 1991 Apr 22;244(1309):63-8. doi: 10.1098/rspb.1991.0052.
3
Phosphorylation of inositol 1,4,5-trisphosphate analogues by 3-kinase and dephosphorylation of inositol 1,3,4,5-tetrakisphosphate analogues by 5-phosphatase.肌醇1,4,5-三磷酸类似物被3-激酶磷酸化以及肌醇1,3,4,5-四磷酸类似物被5-磷酸酶去磷酸化。
Eur J Biochem. 1994 Dec 1;226(2):561-6. doi: 10.1111/j.1432-1033.1994.tb20081.x.
4
Modification at C2 of myo-inositol 1,4,5-trisphosphate produces inositol trisphosphates and tetrakisphosphates with potent biological activities.肌醇1,4,5-三磷酸在C2处的修饰产生具有强大生物活性的肌醇三磷酸和四磷酸。
Eur J Biochem. 1994 Jul 1;223(1):115-24. doi: 10.1111/j.1432-1033.1994.tb18972.x.
5
DL-myo-inositol 1,2,4,5-tetrakisphosphate, a potent analog of D-myo-inositol 1,4,5-trisphosphate.DL-肌醇1,2,4,5-四磷酸，一种有效的D-肌醇1,4,5-三磷酸类似物。
Mol Pharmacol. 1994 Feb;45(2):271-6.
6
Inositol 1,3,4,5,6-pentakisphosphate and inositol hexakisphosphate are inhibitors of the soluble inositol 1,3,4,5-tetrakisphosphate 3-phosphatase and the inositol 1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase from pig brain.肌醇1,3,4,5,6-五磷酸和肌醇六磷酸是猪脑可溶性肌醇1,3,4,5-四磷酸3-磷酸酶以及肌醇1,4,5-三磷酸/肌醇1,3,4,5-四磷酸5-磷酸酶的抑制剂。
Biochem J. 1991 Aug 15;278 ( Pt 1)(Pt 1):219-24. doi: 10.1042/bj2780219.
7
Calcium release activity and metabolism of inositol 1,4,5-trisphosphate in T cells. Modulation by novel inositol 1,4,5-trisphosphate 5-phosphatase inhibitors.
Eur J Biochem. 1994 Jun 1;222(2):515-23. doi: 10.1111/j.1432-1033.1994.tb18893.x.
8
Kinetic analysis of novel inhibitors of inositol polyphosphate metabolism.肌醇多磷酸代谢新型抑制剂的动力学分析
Biochem Biophys Res Commun. 1994 Apr 15;200(1):8-15. doi: 10.1006/bbrc.1994.1407.
9
Roles for hydroxyl groups of D-myo-inositol 1,4,5-trisphosphate in the recognition by its receptor and metabolic enzymes.D-肌醇1,4,5-三磷酸的羟基在其受体和代谢酶识别中的作用。
J Biol Chem. 1993 Sep 15;268(26):19260-6.
10
Design of potent and selective inhibitors of myo-inositol 1,4,5-trisphosphate 5-phosphatase.肌醇1,4,5-三磷酸5-磷酸酶强效和选择性抑制剂的设计
Biochemistry. 1994 Sep 6;33(35):10763-9. doi: 10.1021/bi00201a025.

本文引用的文献

1
The inositol trisphosphate phosphomonoesterase of the human erythrocyte membrane.人红细胞膜的肌醇三磷酸磷酸单酯酶
Biochem J. 1982 Apr 1;203(1):169-77. doi: 10.1042/bj2030169.
2
Rapid formation of inositol 1,3,4,5-tetrakisphosphate following muscarinic receptor stimulation of rat cerebral cortical slices.毒蕈碱受体刺激大鼠大脑皮层切片后肌醇1,3,4,5-四磷酸的快速形成。
Biochem J. 1985 Nov 15;232(1):211-5. doi: 10.1042/bj2320211.
3
Micro-injection of inositol 1,3,4,5-tetrakisphosphate activates sea urchin eggs by a mechanism dependent on external Ca2+.微量注射肌醇1,3,4,5 - 四磷酸通过一种依赖于细胞外钙离子的机制激活海胆卵。
Biochem J. 1986 Dec 15;240(3):917-20. doi: 10.1042/bj2400917.
4
Specific binding sites for [3H]inositol(1,3,4,5)tetrakisphosphate on membranes of HL-60 cells.HL-60细胞细胞膜上[3H]肌醇（1,3,4,5）四磷酸的特异性结合位点
Biochem Biophys Res Commun. 1987 Dec 16;149(2):680-5. doi: 10.1016/0006-291x(87)90421-9.
5
Inositol(1,3,4,5)tetrakisphosphate-induced activation of sea urchin eggs requires the presence of inositol trisphosphate.肌醇（1,3,4,5）四磷酸诱导的海胆卵激活需要三磷酸肌醇的存在。
Biochem Biophys Res Commun. 1987 Jul 15;146(1):284-90. doi: 10.1016/0006-291x(87)90723-6.
6
Formation of inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate from inositol 1,3,4,5-tetrakisphosphate and their pathways of degradation in RBL-2H3 cells.RBL-2H3细胞中由肌醇1,3,4,5-四磷酸形成肌醇1,4,5-三磷酸和肌醇1,3,4-三磷酸及其降解途径。
J Biol Chem. 1988 Oct 5;263(28):14245-50.
7
Metabolism of inositol 1,3,4,5-tetrakisphosphate by human erythrocyte membranes. A new mechanism for the formation of inositol 1,4,5-trisphosphate.人红细胞膜对肌醇1,3,4,5-四磷酸的代谢。肌醇1,4,5-三磷酸形成的新机制。
Biochem J. 1988 May 1;251(3):927-9. doi: 10.1042/bj2510927.
8
The metabolism of tris- and tetraphosphates of inositol by 5-phosphomonoesterase and 3-kinase enzymes.肌醇三磷酸酯和四磷酸酯在5-磷酸单酯酶和3-激酶作用下的代谢
J Biol Chem. 1987 Feb 15;262(5):2146-9.
9
Inositol trisphosphate isomers, but not inositol 1,3,4,5-tetrakisphosphate, induce calcium influx in Xenopus laevis oocytes.肌醇三磷酸异构体可诱导非洲爪蟾卵母细胞中的钙内流，但肌醇1,3,4,5 - 四磷酸则不能。
J Biol Chem. 1988 Aug 15;263(23):11048-51.
10
Inositol phosphates: proliferation, metabolism and function.肌醇磷酸：增殖、代谢与功能
Philos Trans R Soc Lond B Biol Sci. 1988 Jul 26;320(1199):281-98. doi: 10.1098/rstb.1988.0077.

合成肌醇1,3,4,5-四磷酸类似物。

Synthetic inositol 1,3,4,5-tetrakisphosphate analogues.

作者信息

Hirata M, Kimura Y, Ishimatsu T, Yanaga F, Shuto T, Sasaguri T, Koga T, Watanabe Y, Ozaki S

机构信息

Department of Biochemistry, Faculty of Dentistry, Kyushu University, Fukuoka, Japan.

出版信息

Biochem J. 1991 Jun 1;276 ( Pt 2)(Pt 2):333-6. doi: 10.1042/bj2760333.

DOI:10.1042/bj2760333
PMID:1646597
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1151095/
Abstract

Inositol 1,3,4,5-tetrakisphosphate [Ins(1,3,4,5)P4] analogues were synthesized and their effects on [3H]Ins(1,3,4,5)P4 5-phosphatase, [3H]Ins(1,3,4,5)P4 3-phosphatase and [3H]inositol 1,4,5-trisphosphate [3H]Ins(1,4,5)P3] 5-phosphatase activities were examined. The Ins(1,3,4,5)P4 analogue with the aminobenzoyl group at the 2-position of Ins(1,3,4,5)P4 inhibited the hydrolysis of 5-phosphate of [3H]Ins(1,3,4,5)P4 catalysed by erythrocyte ghosts, with a lower Ki value than seen with Ins(1,3,4,5)P4, whereas the analogue with the aminocyclohexanecarbonyl group at the same position had a higher Ki value. The Ins(1,4,5)P3 analogues that we had previously synthesized were also capable of inhibiting this process, with the same tendency as Ins(1,3,4,5)P4 analogues. Such differences in the potency among Ins(1,3,4,5)P4 and Ins(1,4,5)P3 analogues were applicable to other phosphatase activities, namely [3H]Ins(1,3,4,5)P4 3-phosphatase and [3H]Ins(1,4,5)P3 5-phosphatase. These results suggest that the active sites of these enzymes may catalyse the dephosphorylation in a similar fashion.

摘要

合成了肌醇1,3,4,5 - 四磷酸[Ins(1,3,4,5)P4]类似物，并检测了它们对[3H]Ins(1,3,4,5)P4 5 - 磷酸酶、[3H]Ins(1,3,4,5)P4 3 - 磷酸酶和[3H]肌醇1,4,5 - 三磷酸[3H]Ins(1,4,5)P3] 5 - 磷酸酶活性的影响。在Ins(1,3,4,5)P4的2位带有氨基苯甲酰基的Ins(1,3,4,5)P4类似物抑制了红细胞膜催化的[3H]Ins(1,3,4,5)P4 5 - 磷酸的水解，其Ki值低于Ins(1,3,4,5)P4，而在相同位置带有氨基环己烷羰基的类似物具有更高的Ki值。我们之前合成的Ins(1,4,5)P3类似物也能够抑制这一过程，其趋势与Ins(1,3,4,5)P4类似物相同。Ins(1,3,4,5)P4和Ins(1,4,5)P3类似物之间这种效力的差异也适用于其他磷酸酶活性，即[3H]Ins(1,3,4,5)P4 3 - 磷酸酶和[3H]Ins(1,4,5)P3 5 - 磷酸酶。这些结果表明，这些酶的活性位点可能以类似的方式催化去磷酸化反应。