Nguyen Hung Phi, Zhang Dahai, Lee Uk, Kang Jung Sook, Choi Hong Dae, Son Byeng Wha
Department of Chemistry, Pukyong National University, Busan 608-737, Korea.
J Nat Prod. 2007 Jul;70(7):1188-90. doi: 10.1021/np060552g. Epub 2007 Jun 12.
Dehydroxychlorofusarielin B (1), a new antibacterial polyoxygenated decalin derivative, and the previously described fusarielins A (2) and B (3) have been isolated from the broth of a marine isolate of the fungus Aspergillus. The structure and absolute stereochemistry of the new compound was determined on the basis of the physicochemical data and X-ray diffraction. Compounds 1-3 exhibited a mild antibacterial activity against Staphylococcus aureus, methicillin-resistant S. aureus, and multidrug-resistant S. aureus. The MIC values for each strain were as follows: compounds 1 and 3, 62.5 microg/mL for all strains; compound 2, 32.5 microg/mL for S. aureus and methicillin-resistant S. aureus and 62.5 microg/mL for multidrug-resistant S. aureus.
脱羟基氯镰孢菌素B（1），一种新型抗菌多氧化十氢化萘衍生物，以及之前报道的镰孢菌素A（2）和B（3），已从海洋分离真菌曲霉的发酵液中分离得到。基于物理化学数据和X射线衍射确定了新化合物的结构和绝对立体化学。化合物1 - 3对金黄色葡萄球菌、耐甲氧西林金黄色葡萄球菌和多重耐药金黄色葡萄球菌表现出温和的抗菌活性。每种菌株的最低抑菌浓度（MIC）值如下：化合物1和3，对所有菌株均为62.5微克/毫升；化合物2，对金黄色葡萄球菌和耐甲氧西林金黄色葡萄球菌为32.5微克/毫升，对多重耐药金黄色葡萄球菌为62.5微克/毫升。
