Wick Mark R, Patterson James W
Division of Surgical Pathology and Cytopathology, University of Virginia Medical Center, Charlottesville 22908-0214, USA.
Am J Clin Pathol. 2005 Dec;124 Suppl:S52-83. doi: 10.1309/UX3JKQWKJY6B7PEM.
Cutaneous melanocytic proliferations are diverse morphologically, and their behavioral attributes may be difficult to discern with certainty. As a consequence, diagnostic anatomic pathologists regularly encounter problems in the interpretation of such lesions. This review considers several selected issues in that subject area, including proliferative congenital nevi, architecturally disordered (dysplastic) nevi, morphologic variants of Spitz nevus, atypical lentiginous melanocytic proliferations, nevoid melanoma, diagnostically deceptive histologic variants of melanoma, "epidermotropic" metastases of melanoma, and the relationship of melanoma microstages to tumor growth phases.
皮肤黑素细胞增生在形态学上具有多样性,其行为特征可能难以确切辨别。因此,诊断解剖病理学家在解释此类病变时经常遇到问题。本综述探讨了该领域中几个选定的问题,包括增生性先天性痣、结构紊乱(发育异常)痣、Spitz痣的形态学变异、非典型雀斑样黑素细胞增生、痣样黑色素瘤、具有诊断欺骗性的黑色素瘤组织学变异、黑色素瘤的“亲表皮性”转移以及黑色素瘤微分期与肿瘤生长阶段的关系。