Hastrup N, Hou-Jensen K
Department of Pathology, Rigshospitalet, University of Copenhagen, Denmark.
APMIS. 1993 Nov;101(11):845-50. doi: 10.1111/j.1699-0463.1993.tb00190.x.
This study reviews a total of 1000 melanocytic lesions--two separate 500 consecutive sample groupings from 1980 and 1989, respectively--diagnosed in a private non-hospital-associated pathology practice. Lesions were classified as lentigo simplex, congenital nevus, "common" nevus, dysplastic nevus, blue nevus, Spitz's nevus or malignant melanoma. A comparison of the two periods reveals an increase in dysplastic nevi from one in 1980 to nine in 1989. The histologic changes in these nevi were compared to those of the other tumors. Pronounced cytologic atypia was seen in the melanocytes of a few "common" nevi, but more often in the dysplastic nevi and in all of the melanomas. Slight nuclear atypia was usual in "common" nevi and lentigines, and also fibroplasia, lymphocytic infiltration, vessel proliferation and pigment incontinence were seen in both "common" nevi and dysplastic nevi. It is concluded that no single histologic variable was specific for dysplastic nevi.
本研究回顾了总共1000例黑素细胞病变——分别来自1980年和1989年的两个独立的连续500例样本组——这些病变诊断于一家与医院无关的私立病理诊所。病变被分类为单纯性雀斑样痣、先天性痣、“普通”痣、发育异常痣、蓝痣、斯皮茨痣或恶性黑色素瘤。两个时期的比较显示，发育异常痣从1980年的1例增加到1989年的9例。将这些痣的组织学变化与其他肿瘤的组织学变化进行了比较。在一些“普通”痣的黑素细胞中可见明显的细胞学异型性，但在发育异常痣和所有黑色素瘤中更常见。“普通”痣和雀斑样痣中通常有轻微的核异型性，并且在“普通”痣和发育异常痣中均可见纤维组织增生、淋巴细胞浸润、血管增生和色素失禁。得出的结论是，没有单一的组织学变量对发育异常痣具有特异性。
