[毒鼠强中毒大鼠脑内细胞色素C的表达]
[Expression of Cyt C in brain of rats poisoned by tetramine].
作者信息
Li Bin, Chen Wei-jia, Yan Hong-tao, Wu Jing-jie, Jin Bo, Liao Zhi-gang
机构信息
Department of Forensic Pathology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China.
出版信息
Sichuan Da Xue Xue Bao Yi Xue Ban. 2006 Jan;37(1):27-9.
OBJECTIVE
To investigate the evidence for the judgement on legal cases of intoxication by tetramine.
METHODS
Fifty rats given tetramine by lavage were sacrificed at different time after intoxication. The expression of Cyt C was detected by immunohistochemistry, and the reasults were assessed by an image analysis system.
RESULTS
There was a slight expression of Cyt C in control group. In intoxication group the expression of Cyt C increased after the rats were given tetramine for 30 minutes; it reached the peak at 24 hours after intoxication and kept up the level for 3 days, then it began to decrease and returned to the control level in 10 days.
CONCLUSION
The regular change of Cyt C expression might be a useful sign for assessment in legal cases of intoxication by tetramine.
目的
探讨毒鼠强中毒案件鉴定依据。
方法
50只经灌胃给予毒鼠强的大鼠在中毒后不同时间处死。采用免疫组化法检测细胞色素C（Cyt C）的表达，并通过图像分析系统进行结果评估。
结果
对照组Cyt C呈轻度表达。中毒组大鼠给予毒鼠强30分钟后Cyt C表达增加；中毒后24小时达到高峰，并持续3天，之后开始下降，10天后恢复至对照水平。
结论
Cyt C表达的规律性变化可能是毒鼠强中毒案件鉴定的有用指标。
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