Lo Ting Ling, Fong Chee Wai, Yusoff Permeen, McKie Arthur B, Chua Mei-Sze, Leung Hing Y, Guy Graeme R
Signal Transduction laboratory, Institute of Molecular and Cell Biology, 61 Biopolis Drive, #6-01, Proteos, Singapore, 138673.
Cancer Lett. 2006 Oct 28;242(2):141-50. doi: 10.1016/j.canlet.2005.12.032. Epub 2006 Feb 8.
The Ras/Erk signaling pathway has a central role in development of multi-cellular organisms as well as in signal transmission in the mature individual. Recently, a family of genes, designated Sprouty, induced by the Ras/Erk pathway was found to specify proteins that inhibited the upstream pathway. Being in a position that is likely to control well-characterized oncogene products suggested that the expression levels of the Sprouty genes may be relevant in human carcinogenesis. Early data on the deregulation of Sprouty expression in breast, prostate and liver cancers is discussed along with the notion that some of them might have potential as tumour markers or that the derived proteins may act as tumour suppressors.
Ras/Erk信号通路在多细胞生物的发育以及成熟个体的信号传递中起着核心作用。最近，发现了一个由Ras/Erk通路诱导的名为Sprouty的基因家族，该家族可产生抑制上游通路的蛋白质。处于可能控制已明确的癌基因产物的位置，这表明Sprouty基因的表达水平可能与人类致癌作用相关。本文讨论了乳腺癌、前列腺癌和肝癌中Sprouty表达失调的早期数据，以及其中一些基因可能具有作为肿瘤标志物的潜力或其衍生蛋白可能作为肿瘤抑制因子的观点。
