Tarbell Kristin V, Yamazaki Sayuri, Steinman Ralph M
Laboratory of Cellular Physiology and Immunology and the Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, 1230 York Avenue, Box 176, New York, NY 10021-6399, USA.
Semin Immunol. 2006 Apr;18(2):93-102. doi: 10.1016/j.smim.2006.01.009. Epub 2006 Feb 15.
Dendritic cells (DCs) are important for several aspects of the development and function of CD4(+) CD25(+) regulatory T cells (Tregs), which are critical for maintaining peripheral tolerance and preventing autoimmunity. In cultures from human thymus, dendritic cells (DCs) conditioned with thymic stromal lymphopoietin (TSLP) mediate the production of Tregs from CD4(+) CD25(-) thymocytes. In cultures from mouse lymphoid organs, CD86-rich DCs induce the proliferation and improved suppressive function of antigen-specific Tregs. DC-expanded, antigen-specific Tregs show greatly enhanced efficacy relative to polyclonal populations in blocking experimental autoimmunity. In several animal models including NOD diabetes, Tregs directed to one autoantigen are able to block autoimmunity induced by multiple antigens from the target organ. Distinct states of DC differentiation or maturation are likely to be important for the emerging roles of DCs in the biology of Tregs, particularly the control of autoimmunity in an antigen-dependent manner.
树突状细胞（DCs）对于CD4(+) CD25(+)调节性T细胞（Tregs）的发育和功能的多个方面都很重要，而Tregs对于维持外周耐受和预防自身免疫至关重要。在人胸腺培养物中，用胸腺基质淋巴细胞生成素（TSLP）处理的树突状细胞（DCs）介导CD4(+) CD25(-)胸腺细胞产生Tregs。在小鼠淋巴器官培养物中，富含CD86的DCs诱导抗原特异性Tregs的增殖并改善其抑制功能。与多克隆群体相比，DC扩增的抗原特异性Tregs在阻断实验性自身免疫方面显示出大大增强的功效。在包括NOD糖尿病在内的几种动物模型中，针对一种自身抗原的Tregs能够阻断由靶器官的多种抗原诱导的自身免疫。DC分化或成熟的不同状态可能对于DCs在Tregs生物学中的新作用很重要，特别是以抗原依赖性方式控制自身免疫。
