Guo Qing
Department of Physiology, University of Oklahoma Health Sciences Center, College of Medicine, Oklahoma City, OK 73104, USA.
Sci Aging Knowledge Environ. 2006 Feb 8;2006(5):pe5. doi: 10.1126/sageke.2006.5.pe5.
The cyclin-dependent kinase-5 (Cdk5) is critical to normal mammalian development and has been implicated in synaptic plasticity, learning, and memory in the adult brain. But Cdk-5 activity has also been linked to neurodegenerative diseases. Could a single protein have opposing effects? A new study shows that production of a neuronal protein capable of regulating Cdk-5 activity can turn Cdk-5 from "good" to "bad." The findings may have implications for the development and treatment of conditions like Alzheimer's disease.
细胞周期蛋白依赖性激酶5（Cdk5）对哺乳动物的正常发育至关重要，并且与成人大脑的突触可塑性、学习和记忆有关。但Cdk-5的活性也与神经退行性疾病有关。一种蛋白质会产生相反的作用吗？一项新的研究表明，一种能够调节Cdk-5活性的神经元蛋白的产生可以使Cdk-5从“好”变“坏”。这些发现可能对阿尔茨海默病等疾病的发展和治疗具有启示意义。
