Cdk5: A main culprit in neurodegeneration.

Neurodegenerative diseases (NDs) such as Alzheimer Diseases (AD), Parkinson Diseases (PD) are a huge public health problem. The elucidation of their pathophysiological mechanism is one of our greatest challenges. Hyperactive immune system contributes to the pathophysiology of neurological disorders. In this review article, we have highlighted the neurodegenerative role of CDK5 and its involvement in Amyloid precursor pathway via Beta secretase enzyme. All the landmark research reports for CDK5 were considered for this review and its involvement in disrupted autophagy and hyper immune response is the key cause for neurodegeneration. In conclusion, the present review focus on the pathways associated with Cdk5 and its role in causing neurodegeneration.