Department of Bioinformatics, Alagappa University , Karaikudi , Tamilnadu , India.
Int J Neurosci. 2019 Dec;129(12):1192-1197. doi: 10.1080/00207454.2019.1645142. Epub 2019 Sep 13.
Neurodegenerative diseases (NDs) such as Alzheimer Diseases (AD), Parkinson Diseases (PD) are a huge public health problem. The elucidation of their pathophysiological mechanism is one of our greatest challenges. Hyperactive immune system contributes to the pathophysiology of neurological disorders. In this review article, we have highlighted the neurodegenerative role of CDK5 and its involvement in Amyloid precursor pathway via Beta secretase enzyme. All the landmark research reports for CDK5 were considered for this review and its involvement in disrupted autophagy and hyper immune response is the key cause for neurodegeneration. In conclusion, the present review focus on the pathways associated with Cdk5 and its role in causing neurodegeneration.
神经退行性疾病（NDs），如阿尔茨海默病（AD）、帕金森病（PD），是一个巨大的公共卫生问题。阐明其病理生理学机制是我们面临的最大挑战之一。过度活跃的免疫系统是导致神经紊乱的病理生理学原因之一。在这篇综述文章中，我们强调了 CDK5 的神经退行性作用及其通过β-分泌酶参与淀粉样前体途径。所有关于 CDK5 的重要研究报告都被纳入了本次综述，其对自噬和过度免疫反应的破坏是导致神经退行性变的关键原因。总之，本综述重点关注与 Cdk5 相关的途径及其导致神经退行性变的作用。
