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1
The MCK enhancer contains a p53 responsive element.MCK增强子包含一个p53反应元件。
Proc Natl Acad Sci U S A. 1991 Jun 1;88(11):4570-1. doi: 10.1073/pnas.88.11.4570.
2
Different E-box regulatory sequences are functionally distinct when placed within the context of the troponin I enhancer.当置于肌钙蛋白I增强子的背景下时，不同的E盒调控序列在功能上是不同的。
Nucleic Acids Res. 1992 Oct 11;20(19):5105-13. doi: 10.1093/nar/20.19.5105.
3
DNA binding and transcriptional regulatory activity of mammalian achaete-scute homologous (MASH) proteins revealed by interaction with a muscle-specific enhancer.通过与肌肉特异性增强子相互作用揭示的哺乳动物无刚毛-小盾片同源（MASH）蛋白的DNA结合和转录调控活性
Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3596-600. doi: 10.1073/pnas.89.8.3596.
4
p53 protein is activated during muscle differentiation and participates with MyoD in the transcription of muscle creatine kinase gene.p53蛋白在肌肉分化过程中被激活，并与MyoD共同参与肌肉肌酸激酶基因的转录。
Oncogene. 1998 Jul 23;17(3):347-56. doi: 10.1038/sj.onc.1201929.
5
Multiple regulatory elements contribute differentially to muscle creatine kinase enhancer activity in skeletal and cardiac muscle.多种调控元件对骨骼肌和心肌中肌酸激酶增强子活性的贡献各不相同。
Mol Cell Biol. 1993 May;13(5):2753-64. doi: 10.1128/mcb.13.5.2753-2764.1993.
6
p53-dependent activation of the mouse MCK gene promoter: identification of a novel p53-responsive sequence and evidence for cooperation between distinct p53 binding sites.小鼠肌酸激酶基因（MCK）启动子的p53依赖性激活：一个新的p53反应序列的鉴定以及不同p53结合位点之间协同作用的证据
Gene Expr. 1995;5(1):19-33.
7
Rabbit muscle creatine kinase: genomic cloning, sequencing, and analysis of upstream sequences important for expression in myocytes.兔肌肉肌酸激酶：基因组克隆、测序及对在肌细胞中表达至关重要的上游序列分析
Nucleic Acids Res. 1991 Jun 11;19(11):3027-33. doi: 10.1093/nar/19.11.3027.
8
Overlap of the p53-responsive element and cAMP-responsive element in the enhancer of human T-cell leukemia virus type I.人类T细胞白血病病毒I型增强子中p53反应元件与cAMP反应元件的重叠
Proc Natl Acad Sci U S A. 1992 Jun 15;89(12):5403-7. doi: 10.1073/pnas.89.12.5403.
9
Identification of a myocyte nuclear factor that binds to the muscle-specific enhancer of the mouse muscle creatine kinase gene.一种与小鼠肌肉肌酸激酶基因的肌肉特异性增强子结合的心肌细胞核因子的鉴定。
Mol Cell Biol. 1989 Jun;9(6):2627-40. doi: 10.1128/mcb.9.6.2627-2640.1989.
10
MyoD binds cooperatively to two sites in a target enhancer sequence: occupancy of two sites is required for activation.肌细胞决定蛋白（MyoD）与靶增强子序列中的两个位点协同结合：激活需要占据这两个位点。
Proc Natl Acad Sci U S A. 1990 Aug;87(15):5623-7. doi: 10.1073/pnas.87.15.5623.

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The ubiquitin-proteasome system in regulation of the skeletal muscle homeostasis and atrophy: from basic science to disorders.泛素-蛋白酶体系统在调节骨骼肌动态平衡和萎缩中的作用：从基础科学到疾病。
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The Ubiquitin-Proteasome System Is Indispensable for the Maintenance of Muscle Stem Cells.泛素-蛋白酶体系统对于肌肉干细胞的维持是不可或缺的。
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Transcriptional activator TAp63 is upregulated in muscular atrophy during ALS and induces the pro-atrophic ubiquitin ligase Trim63.转录激活因子TAp63在肌萎缩侧索硬化症（ALS）期间的肌肉萎缩中上调，并诱导促萎缩泛素连接酶Trim63。
Elife. 2016 Feb 26;5:e10528. doi: 10.7554/eLife.10528.
5
p53 suppresses muscle differentiation at the myogenin step in response to genotoxic stress.p53 在基因毒性应激反应中，于生肌调节因子阶段抑制肌肉分化。
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Mitochondrial p53 mediates a transcription-independent regulation of cell respiration and interacts with the mitochondrial F₁F0-ATP synthase.线粒体 p53 介导细胞呼吸的转录独立调节，并与线粒体 F₁F0-ATP 合酶相互作用。
Cell Cycle. 2013 Sep 1;12(17):2781-93. doi: 10.4161/cc.25870. Epub 2013 Aug 6.
7
p53: a molecular marker for the detection of cancer.p53：一种用于癌症检测的分子标志物。
Expert Opin Med Diagn. 2008 Sep;2(9):1013-24. doi: 10.1517/17530059.2.9.1013.
8
Homeostatic functions of the p53 tumor suppressor: regulation of energy metabolism and antioxidant defense.p53肿瘤抑制因子的稳态功能：能量代谢与抗氧化防御的调节
Semin Cancer Biol. 2009 Feb;19(1):32-41. doi: 10.1016/j.semcancer.2008.11.005. Epub 2008 Dec 3.
9
Muscle cachexia is regulated by a p53-PW1/Peg3-dependent pathway.肌肉恶病质由一条p53-PW1/Peg3依赖性途径调控。
Genes Dev. 2006 Dec 15;20(24):3440-52. doi: 10.1101/gad.412606.
10
The MyoD-inducible p204 protein overcomes the inhibition of myoblast differentiation by Id proteins.由MyoD诱导产生的p204蛋白可克服Id蛋白对成肌细胞分化的抑制作用。
Mol Cell Biol. 2002 May;22(9):2893-905. doi: 10.1128/MCB.22.9.2893-2905.2002.

本文引用的文献

1
Overproduction of p53 antigen makes established cells highly tumorigenic.p53抗原的过度产生会使成熟细胞具有高度致瘤性。
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DNA binding properties of murine p53.小鼠p53的DNA结合特性
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Clonal analysis of human colorectal tumors.人类结肠肿瘤的克隆分析。
Science. 1987 Oct 9;238(4824):193-7. doi: 10.1126/science.2889267.
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Genetic alterations during colorectal-tumor development.结直肠癌发生发展过程中的基因改变。
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Muscle creatine kinase sequence elements regulating skeletal and cardiac muscle expression in transgenic mice.调节转基因小鼠骨骼肌和心肌表达的肌肉肌酸激酶序列元件。
Mol Cell Biol. 1989 Aug;9(8):3393-9. doi: 10.1128/mcb.9.8.3393-3399.1989.
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Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD.通过强制表达MyoD在色素、神经、脂肪、肝脏和成纤维细胞系中激活肌肉特异性基因。
Proc Natl Acad Sci U S A. 1989 Jul;86(14):5434-8. doi: 10.1073/pnas.86.14.5434.
7
Mutations in the p53 gene occur in diverse human tumour types.p53基因的突变发生在多种人类肿瘤类型中。
Nature. 1989 Dec 7;342(6250):705-8. doi: 10.1038/342705a0.
8
Wild-type p53 can inhibit oncogene-mediated focus formation.野生型p53可抑制癌基因介导的集落形成。
Proc Natl Acad Sci U S A. 1989 Nov;86(22):8763-7. doi: 10.1073/pnas.86.22.8763.
9
The p53 proto-oncogene can act as a suppressor of transformation.p53原癌基因可作为转化抑制因子。
Cell. 1989 Jun 30;57(7):1083-93. doi: 10.1016/0092-8674(89)90045-7.
10
MyoD binds cooperatively to two sites in a target enhancer sequence: occupancy of two sites is required for activation.肌细胞决定蛋白（MyoD）与靶增强子序列中的两个位点协同结合：激活需要占据这两个位点。
Proc Natl Acad Sci U S A. 1990 Aug;87(15):5623-7. doi: 10.1073/pnas.87.15.5623.

MCK增强子包含一个p53反应元件。

The MCK enhancer contains a p53 responsive element.

作者信息

Weintraub H, Hauschka S, Tapscott S J

机构信息

Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98104.

出版信息

Proc Natl Acad Sci U S A. 1991 Jun 1;88(11):4570-1. doi: 10.1073/pnas.88.11.4570.

DOI:10.1073/pnas.88.11.4570
PMID:1647009
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC51706/
Abstract

p53 is an antioncogene that is defective or absent in a large number of human tumors. Its function in normal cells is not known. We show that co-transfection of mouse p53 with muscle-specific creatine kinase-chloramphenicol acetyltransferase reporter gene, containing 3.3 kilobase of upstream control sequence for the muscle-specific creatine kinase gene, results in a 10- to 80-fold activation. The p53 responsive element maps to a region distinguished from the known MyoD binding region. Identification of a p53 responsive element should allow a more focused analysis of the effects of p53 in controlling gene activity.

摘要

p53是一种抗癌基因，在大量人类肿瘤中存在缺陷或缺失。其在正常细胞中的功能尚不清楚。我们发现，将小鼠p53与肌肉特异性肌酸激酶-氯霉素乙酰转移酶报告基因共转染，该报告基因含有3.3千碱基的肌肉特异性肌酸激酶基因上游控制序列，可导致10至80倍的激活。p53反应元件定位于一个与已知MyoD结合区域不同的区域。p53反应元件的鉴定应有助于更有针对性地分析p53在控制基因活性方面的作用。