Suh Sang-il, Seol Hae Young, Lee Jean Hwa, Lee Young Hen, Kim Taik-Kun, Lee Nam Joon, Woo Jeong-Soo, Kim In Sun
Department of Diagnostic Radiology, Korea University, School of Medicine, Seoul, South Korea.
Head Neck. 2006 Apr;28(4):369-72. doi: 10.1002/hed.20413.
Inflammatory myofibroblastic tumor, composed of myofibroblastic spindle cells with acute and chronic inflammatory cells, is an unusual, benign solid mass that mimics a neoplastic process.
We report a rare case of a patient with a laryngeal inflammatory myofibroblastic tumor. Laryngoscopy demonstrated a submucosal mass involving the right false cord. The mass was a well-enhanced supraglottic lesion on CT scan. It showed medially high signal intensity and peripherally low signal intensity on T2-weighted MR images, and it displayed a high magnetization transfer ratio; before surgery, it was believed to be a malignant tumor. Laryngoscopic biopsy was performed. Pathologic features of the specimen were diagnostic for inflammatory myofibroblastic tumor.
Steroid therapy was chosen for further treatment. No recurrence was observed for 4 years.
In patients with chronic hoarseness who have a malignant-looking submucosal laryngeal mass, inflammatory myofibroblastic tumor should be considered. Conservative surgery and steroid treatment are advocated because of laryngeal preservation.
炎性肌纤维母细胞瘤由肌纤维母细胞性梭形细胞与急性和慢性炎症细胞组成，是一种罕见的良性实性肿块，易被误诊为肿瘤性病变。
我们报告一例罕见的喉炎性肌纤维母细胞瘤患者。喉镜检查显示右侧假声带处有一黏膜下肿块。CT扫描显示该肿块为声门上强化良好的病变。在T2加权磁共振图像上，其内侧呈高信号强度，外周呈低信号强度，且磁化传递率较高；手术前，该病变被认为是恶性肿瘤。进行了喉镜活检。标本的病理特征确诊为炎性肌纤维母细胞瘤。
选择类固醇治疗作为进一步治疗方法。4年未观察到复发。
对于患有看似恶性的喉黏膜下肿块且伴有慢性声音嘶哑的患者，应考虑炎性肌纤维母细胞瘤。由于可保留喉部，提倡采用保守手术和类固醇治疗。
