Idrees Muhammud T, Huan Youming, Woo Peak, Wang Beverly Y
Department of Pathology, The Mount Sinai School of Medicine, New York, NY 10029, USA.
Ann Diagn Pathol. 2007 Dec;11(6):433-9. doi: 10.1016/j.anndiagpath.2007.04.004. Epub 2007 Oct 24.
Inflammatory myofibroblastic tumor is a recently characterized lesion, composed of exuberant myofibroblastic proliferation and an inflammatory component. Its etiology remains controversial, as to whether this represents a benign tumor with limited potential to recur or progress. Exaggerated response to trauma or infection has also been implicated. Only a few cases of laryngeal inflammatory myofibroblastic tumor have been described in English after it has been assigned the new name. The prototype lesion, inflammatory pseudotumor, has been best described in association with the lung but has also been reported involving various organs. We report 2 additional cases with a considerable variation in the presentation and histology of the lesion, thus expanding the morphological spectrum of the entity. Both lesions appeared aggressive in clinical presentation. One case had relatively more pleomorphic appearance and increased mitotic rate. Both lesions were surgically resected, and complete voice preservation was achieved. No postoperative complications or recurrence were noticed. This uncommon neoplasm may appear clinically as a large infiltrating mass and may be mistaken as a malignant growth. Conservative resection of the tumor may provide a cure with adequate voice preservation.
炎性肌成纤维细胞瘤是一种最近才被明确特征的病变，由旺盛的肌成纤维细胞增殖和炎症成分组成。其病因仍存在争议，它究竟是一种复发或进展潜能有限的良性肿瘤尚不明确。对创伤或感染的过度反应也被认为与之有关。在被赋予这个新名称后，仅有少数英文报道的喉炎性肌成纤维细胞瘤病例。原型病变，即炎性假瘤，在与肺相关的情况中描述得最为详尽，但也有累及各种器官的报道。我们报告另外2例病例，其病变的表现和组织学有相当大的差异，从而扩展了该实体的形态学谱。两例病变在临床表现上均显得具有侵袭性。其中1例有相对更多的多形性表现且有丝分裂率增加。两例病变均接受了手术切除，并且实现了完全的声音保留。未观察到术后并发症或复发情况。这种罕见的肿瘤在临床上可能表现为巨大的浸润性肿块，可能会被误诊为恶性生长。对肿瘤进行保守切除可能在充分保留声音的情况下实现治愈。
