Akopov S E, Grigorian G S, Tunian Iu S, Gabrielian E S
Zh Nevropatol Psikhiatr Im S S Korsakova. 1991;91(1):67-71.
Three hours after administration of a single 20 mg dose of nifedipine the platelet, leucocyte and red blood cells aggregation was inhibited with the red blood cells and leucocytes deformability increased. This effect proved sensitive to the plasma nifedipine concentration disappearing with its concentrations below 25 ng/ml. The nifedipine sensitivity of the blood cells was the second factor influencing its effect. This was closely related to prostacyclin. The blood cells sensitivity to the latter, and its plasma concentration and decay rates were major determinants of the nifedipine capability of inhibiting the leucocyte, red blood cells and especially platelet inhibition.
单次给予20毫克硝苯地平三小时后，血小板、白细胞和红细胞的聚集受到抑制，同时红细胞和白细胞的变形能力增强。这一效应被证明对血浆硝苯地平浓度敏感，当浓度低于25纳克/毫升时该效应消失。血细胞对硝苯地平的敏感性是影响其效应的第二个因素。这与前列环素密切相关。血细胞对前列环素的敏感性、其血浆浓度和衰减率是硝苯地平抑制白细胞、红细胞尤其是血小板聚集能力的主要决定因素。
